Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | histone deacetylase, putative | 0.1041 | 0.9786 | 0.9627 |
Echinococcus granulosus | histone deacetylase 6 | 0.1041 | 0.9786 | 0.9786 |
Brugia malayi | histone deacetylase 11 | 0.0477 | 0.4263 | 0.4244 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0477 | 0.4263 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.1063 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.0477 | 0.4263 | 0.4263 |
Echinococcus granulosus | histone deacetylase 1 | 0.1063 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.1063 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.1063 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.1063 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1041 | 0.9786 | 0.9786 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.4263 | 0.4218 |
Echinococcus granulosus | histone deacetylase 6 | 0.1041 | 0.9786 | 0.9786 |
Echinococcus multilocularis | histone deacetylase | 0.1041 | 0.9786 | 0.9786 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1041 | 0.9786 | 0.9627 |
Echinococcus multilocularis | histone deacetylase 3 | 0.1063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.5318 | 0.5282 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1063 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.1041 | 0.9786 | 0.9784 |
Leishmania major | histone deacetylase, putative | 0.1063 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1063 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0188 | 0.0188 |
Trypanosoma brucei | histone deacetylase 3 | 0.1041 | 0.9786 | 0.9627 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0477 | 0.4263 | 0.4263 |
Brugia malayi | Histone deacetylase family protein | 0.1041 | 0.9786 | 0.9785 |
Echinococcus multilocularis | histone deacetylase 7 | 0.1041 | 0.9786 | 0.9786 |
Plasmodium falciparum | histone deacetylase 1 | 0.1063 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1061 | 0.9982 | 0.9982 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0477 | 0.4263 | 0.4218 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1063 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.1063 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.1063 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.1061 | 0.9982 | 0.9982 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0188 | 0.0188 |
Brugia malayi | Histone deacetylase 1 | 0.1063 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.1063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1063 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.1063 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1041 | 0.9786 | 0.9786 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0078 | 0.0045 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0477 | 0.4263 | 0.4263 |
Entamoeba histolytica | histone deacetylase, putative | 0.1063 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1063 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1063 | 1 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.1041 | 0.9786 | 0.9785 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1041 | 0.9786 | 0.9786 |
Plasmodium vivax | histone deacetylase 2, putative | 0.1041 | 0.9786 | 0.9627 |
Leishmania major | histone deacetylase, putative | 0.1063 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.1063 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.1063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0188 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.5122 | 0.5084 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0477 | 0.4263 | 0.4263 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1041 | 0.9786 | 0.9627 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1041 | 0.9786 | 0.9627 |
Echinococcus granulosus | histone deacetylase 3 | 0.1063 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.1041 | 0.9786 | 0.9784 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1063 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1063 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1063 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1041 | 0.9786 | 0.9786 |
Trypanosoma brucei | histone deacetylase 4 | 0.1041 | 0.9786 | 0.9627 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1063 | 1 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.1041 | 0.9786 | 0.9627 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0143 | 0.0143 |
Echinococcus granulosus | histone deacetylase 7 | 0.1041 | 0.9786 | 0.9786 |
Echinococcus granulosus | histone deacetylase 6 | 0.1061 | 0.9982 | 0.9982 |
Echinococcus granulosus | histone deacetylase | 0.1041 | 0.9786 | 0.9786 |
Schistosoma mansoni | histone deacetylase | 0.1063 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1063 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.1041 | 0.9786 | 0.9627 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1063 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1590 nM | Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | ChEMBL. | 17936624 |
IC50 (functional) | = 1590 nM | Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | ChEMBL. | 17936624 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.