Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ryanodine receptor 44f | 0.0163 | 0.3888 | 1 |
Plasmodium falciparum | superoxide dismutase [Fe] | 0.0066 | 0.0691 | 0.5 |
Trypanosoma cruzi | iron superoxide dismutase, putative | 0.0066 | 0.0691 | 0.1103 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0107 | 0.2066 | 1 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.0107 | 0.2066 | 0.2468 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0283 | 0.786 | 1 |
Chlamydia trachomatis | superoxide dismutase | 0.0066 | 0.0691 | 0.5 |
Trichomonas vaginalis | superoxide dismutase [fe], putative | 0.0066 | 0.0691 | 0.5 |
Trypanosoma cruzi | iron superoxide dismutase A, mitochondrial | 0.0066 | 0.0691 | 0.1103 |
Onchocerca volvulus | Superoxide dismutase [Mn], mitochondrial homolog | 0.0066 | 0.0691 | 1 |
Onchocerca volvulus | Superoxide dismutase [Mn], mitochondrial homolog | 0.0066 | 0.0691 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0185 | 0.4628 | 0.5582 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5831 | 1 |
Mycobacterium leprae | Probable superoxide dismutase SodA | 0.0066 | 0.0691 | 0.5 |
Trichomonas vaginalis | superoxide dismutase [mn], putative | 0.0066 | 0.0691 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0691 | 0.0277 |
Trypanosoma cruzi | iron superoxide dismutase, putative | 0.0066 | 0.0691 | 0.1103 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0126 | 0.2684 | 0.6236 |
Trypanosoma cruzi | iron superoxide dismutase, putative | 0.0066 | 0.0691 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5693 | 0.9738 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0107 | 0.2066 | 0.2081 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0107 | 0.2066 | 1 |
Mycobacterium ulcerans | superoxide dismutase [Fe] SodA | 0.0066 | 0.0691 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.4628 | 0.7724 |
Trypanosoma brucei | cAMP-specific phosphodiesterase, putative | 0.0234 | 0.6263 | 1 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0227 | 0.6028 | 0.5733 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0107 | 0.2066 | 0.4303 |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0107 | 0.2066 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0192 | 0.4851 | 0.7745 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0192 | 0.4851 | 0.7465 |
Entamoeba histolytica | iron-containing superoxide dismutase | 0.0066 | 0.0691 | 0.5 |
Trichomonas vaginalis | superoxide dismutase [fe], putative | 0.0066 | 0.0691 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3888 | 0.6324 |
Loa Loa (eye worm) | PDE1B protein | 0.0107 | 0.2066 | 0.2879 |
Leishmania major | hypothetical protein, conserved | 0.013 | 0.2822 | 0.3825 |
Trichomonas vaginalis | superoxide dismutase [fe], putative | 0.0066 | 0.0691 | 0.5 |
Mycobacterium tuberculosis | Superoxide dismutase [FE] SodA | 0.0066 | 0.0691 | 0.5 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.0107 | 0.2066 | 0.2468 |
Trichomonas vaginalis | superoxide dismutase, putative | 0.0066 | 0.0691 | 0.5 |
Trichomonas vaginalis | superoxide dismutase, putative | 0.0066 | 0.0691 | 0.5 |
Trypanosoma cruzi | cAMP-specific phosphodiesterase, putative | 0.0234 | 0.6263 | 1 |
Wolbachia endosymbiont of Brugia malayi | superoxide dismutase, SodA | 0.0066 | 0.0691 | 0.5 |
Trypanosoma cruzi | iron superoxide dismutase A, mitochondrial | 0.0066 | 0.0691 | 0.1103 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0126 | 0.2684 | 0.6236 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0107 | 0.2066 | 0.4303 |
Schistosoma mansoni | superoxide dismutase [mn] | 0.0066 | 0.0691 | 0.02 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0107 | 0.2066 | 0.3299 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0107 | 0.2066 | 0.4303 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0107 | 0.2066 | 0.4303 |
Leishmania major | cAMP-specific phosphodiesterase, putative | 0.0234 | 0.6263 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0163 | 0.3888 | 1 |
Trichomonas vaginalis | iron superoxide dismutase A, putative | 0.0066 | 0.0691 | 0.5 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0107 | 0.2066 | 0.3299 |
Schistosoma mansoni | ryanodine receptor related | 0.0227 | 0.6028 | 0.7496 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0107 | 0.2066 | 0.1478 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 50 uM | Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA) | ChEMBL. | 15006379 |
Ki (binding) | > 50 uM | Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA) | ChEMBL. | 15006379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.