Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1345 | 0.4564 | 0.4305 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.281 | 1 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0558 | 0.1642 | 0.1042 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0558 | 0.1642 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0558 | 0.1642 | 0.1042 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0558 | 0.1642 | 0.1243 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0558 | 0.1642 | 0.1042 |
Giardia lamblia | Kinase, CMGC CDK | 0.0558 | 0.1642 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0558 | 0.1642 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0558 | 0.1642 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0558 | 0.1642 | 0.1042 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0558 | 0.1642 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0558 | 0.1642 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 0.067 | 0.0225 |
Plasmodium vivax | protein kinase Crk2 | 0.0558 | 0.1642 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0558 | 0.1642 | 0.2887 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0558 | 0.1642 | 0.1042 |
Giardia lamblia | Kinase, CMGC CDK | 0.0558 | 0.1642 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.281 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0558 | 0.1642 | 0.5 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.281 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0558 | 0.1642 | 0.1042 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0558 | 0.1642 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0558 | 0.1642 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0558 | 0.1642 | 0.2887 |
Loa Loa (eye worm) | hypothetical protein | 0.1345 | 0.4564 | 0.4305 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0558 | 0.1642 | 0.1042 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0558 | 0.1642 | 0.5 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0296 | 0.067 | 0.0522 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0558 | 0.1642 | 0.1243 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0558 | 0.1642 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0558 | 0.1642 | 0.1042 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0558 | 0.1642 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0558 | 0.1642 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0558 | 0.1642 | 0.1042 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0558 | 0.1642 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0558 | 0.1642 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0558 | 0.1642 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.162 | 0.122 |
Brugia malayi | hypothetical protein | 0.1345 | 0.4564 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0558 | 0.1642 | 0.1243 |
Echinococcus granulosus | cyclin dependent kinase | 0.0558 | 0.1642 | 0.1042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.22 nM | Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay | ChEMBL. | 17764937 |
IC50 (binding) | = 0.22 nM | Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assay | ChEMBL. | 17764937 |
IC50 (binding) | = 30 nM | Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta40 production by cell free assay | ChEMBL. | 17764937 |
IC50 (binding) | = 30 nM | Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta40 production by cell free assay | ChEMBL. | 17764937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.