Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.027 | 0.741 | 0.66 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0326 | 1 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0326 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0326 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0326 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0326 | 1 | 1 |
Leishmania major | 0.0326 | 1 | 0.5 | |
Echinococcus multilocularis | nmda type glutamate receptor | 0.027 | 0.741 | 0.741 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0326 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0161 | 0.2382 | 0.2382 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0177 | 0.3106 | 0.3106 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0177 | 0.3106 | 0.0949 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0326 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 15 nM | Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 17927167 |
Ki (binding) | = 15 nM | Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 17927167 |
Ki (binding) | = 389.2 nM | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 17927167 |
Ki (binding) | = 389.2 nM | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 17927167 |
Ki (binding) | > 10000 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 17927167 |
Ki (binding) | > 10000 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 17927167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.