Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.1089 | 0 | 0.5 |
Trypanosoma brucei | Prostaglandin E synthase | 0.1089 | 0 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1089 | 0 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1089 | 0 | 0.5 |
Onchocerca volvulus | 0.1089 | 0 | 0.5 | |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.145613 | 1 | 0.5 |
Onchocerca volvulus | 0.145613 | 1 | 0.5 | |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.145613 | 1 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.145613 | 1 | 0.5 |
Trypanosoma brucei | Prostaglandin E synthase | 0.145613 | 1 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.1089 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.145613 | 1 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0900242 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.145613 | 1 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.145613 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1089 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.1089 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.2 uM | Antiplasmodial activity against chloroquine and pyremethamine-resistant Plasmodium falciparum K1 after 48 hrs by microplate assay | ChEMBL. | 17544672 |
IC50 (functional) | = 0.2 uM | Antiplasmodial activity against chloroquine and pyremethamine-resistant Plasmodium falciparum K1 after 48 hrs by microplate assay | ChEMBL. | 17544672 |
IC50 (functional) | = 0.2 uM | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 | ChEMBL. | 18571774 |
IC50 (functional) | = 0.2 uM | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs as [3H]hypoxanthine uptake | ChEMBL. | 19395265 |
IC50 (functional) | = 0.72 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by microplate assay | ChEMBL. | 17544672 |
IC50 (functional) | = 0.72 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by microplate assay | ChEMBL. | 17544672 |
IC50 (functional) | = 0.72 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 by microplate assay | ChEMBL. | 18571774 |
IC50 (functional) | = 0.72 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by alamar blue assay | ChEMBL. | 19395265 |
IC50 (ADMET) | = 49 uM | Cytotoxicity against rat L6 cells after 72 hrs by microplate assay | ChEMBL. | 17544672 |
Ratio IC50 (functional) | = 68.06 | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense | ChEMBL. | 17544672 |
Ratio IC50 (functional) | = 245 | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1 | ChEMBL. | 17544672 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 17544672 | ||
Plasmodium falciparum | ChEMBL23 | 17544672 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.