Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 3 | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 2 (trypsin 2) | References | |
Homo sapiens | protease, serine, 1 (trypsin 1) | References | |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 2 (trypsin 2) | 247 aa | 240 aa | 25.8 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 3 | 261 aa | 234 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0491 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0491 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0491 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0491 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0491 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0491 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0491 | 1 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0212 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0491 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0491 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0491 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0491 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0347 | 0.4834 | 0.4834 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0347 | 0.4834 | 0.4834 |
Echinococcus granulosus | glycogen phosphorylase | 0.0491 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0491 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0491 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0491 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0491 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0212 | 0 | 0.5 |
Onchocerca volvulus | 0.0347 | 0.4834 | 0.1636 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.5 uM | Anticoagulant potency in human plasma assessed as concentration required to double prothrombin time | ChEMBL. | 17914785 |
Ki (binding) | = 0.25 nM | Binding affinity to human F10a | ChEMBL. | 17914785 |
Ki (binding) | = 0.25 nM | Binding affinity to human F10a | ChEMBL. | 17914785 |
Ki (binding) | = 180 nM | Inhibition of human thrombin | ChEMBL. | 17914785 |
Ki (binding) | = 180 nM | Inhibition of human thrombin | ChEMBL. | 17914785 |
Ki (binding) | > 3000 nM | Inhibition of human trypsin | ChEMBL. | 17914785 |
Ki (binding) | > 3000 nM | Inhibition of human trypsin | ChEMBL. | 17914785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.