Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2385 | 0.7289 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0081 | 0.2691 | 0.2691 |
Brugia malayi | flavodoxin family protein | 0.0081 | 0.2691 | 0.2691 |
Brugia malayi | FAD binding domain containing protein | 0.0081 | 0.2691 | 0.2691 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.1561 | 0.1561 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2385 | 0.7289 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.1561 | 0.1561 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.1561 | 0.1561 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0081 | 0.2691 | 0.2691 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0081 | 0.2691 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0072 | 0.1892 | 0.2924 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2385 | 0.7289 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 0.2691 | 0.2691 |
Leishmania major | p450 reductase, putative | 0.0081 | 0.2691 | 0.0986 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0081 | 0.2691 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1561 | 0.1561 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 0.2691 | 0.2691 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.005 | 0 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.1561 | 0.1561 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2691 | 0.2691 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.2385 | 1 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.1561 | 0.1561 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.1561 | 0.1561 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.1561 | 0.1561 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.1561 | 0.1561 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0081 | 0.2691 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0081 | 0.2691 | 0.0986 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0081 | 0.2691 | 0.2691 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0081 | 0.2691 | 0.2691 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.24 nM | Inhibition of cholesterol synthesis in rat liver hepatocytes after 4 hrs | ChEMBL. | 17560788 |
IC50 (binding) | = 1.6 nM | Inhibition of rat microsomal HMG-CoA reductase assessed as inhibition of cholesterol synthesis after 30 mins | ChEMBL. | 17560788 |
IC50 (binding) | = 1.6 nM | Inhibition of rat microsomal HMG-CoA reductase assessed as inhibition of cholesterol synthesis after 30 mins | ChEMBL. | 17560788 |
IC50 (functional) | = 184 nM | Inhibition of cholesterol synthesis in rat L6 cells after 3 hrs | ChEMBL. | 17560788 |
Inhibition (functional) | Inhibition of cholesterol synthesis in C57/BL6 mouse at 30 mg/kg, po by MAICS assay | ChEMBL. | 17560788 | |
Inhibition (functional) | 0 | Inhibition of cholesterol synthesis in C57/BL6 mouse at 30 mg/kg, po by MAICS assay | ChEMBL. | 17560788 |
Ratio IC50 (functional) | = 770 | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for rat hepatocytes | ChEMBL. | 17560788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.