Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gonadotropin-releasing hormone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | GnHR receptor homolog | Get druggable targets OG5_131719 | All targets in OG5_131719 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0084 | 0.0405 | 0.0901 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Echinococcus multilocularis | AMPK beta subunit | 0.0119 | 0.1117 | 0.2488 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0119 | 0.1117 | 0.0765 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0286 | 0.4491 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase KIN | 0.0084 | 0.0405 | 0.5 |
Onchocerca volvulus | Alicorn homolog | 0.0104 | 0.0812 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0084 | 0.0405 | 0.0901 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0286 | 0.4491 | 1 |
Brugia malayi | putative serine/threonine kinase SADA gamma | 0.0084 | 0.0405 | 0.0024 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0119 | 0.1117 | 1 |
Toxoplasma gondii | histone kinase SNF1, putative | 0.0084 | 0.0405 | 1 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0119 | 0.1117 | 0.0765 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Brugia malayi | loechrig isoform VII | 0.0245 | 0.367 | 0.3419 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0286 | 0.4491 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0084 | 0.0405 | 0.5 |
Echinococcus granulosus | serine:threonine kinase SAD 1 | 0.0084 | 0.0405 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0405 | 0.0056 |
Leishmania major | hypothetical protein, conserved | 0.0119 | 0.1117 | 1 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0119 | 0.1117 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0245 | 0.367 | 0.8172 |
Giardia lamblia | 5-AMP-activated protein kinase, beta-1 subunit | 0.0119 | 0.1117 | 0.2182 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0245 | 0.367 | 0.8172 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.0286 | 0.4491 | 0.4273 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0245 | 0.367 | 0.8172 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0286 | 0.4491 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Echinococcus multilocularis | serine:threonine kinase SAD 1 | 0.0084 | 0.0405 | 0.0901 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0223 | 0.3223 | 0.7177 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Echinococcus granulosus | AMPK beta subunit | 0.0119 | 0.1117 | 0.2488 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0084 | 0.0405 | 0.5 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0245 | 0.367 | 0.8002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0084 | 0.0405 | 0.0901 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0119 | 0.1117 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Schistosoma mansoni | protein kinase subunit beta | 0.0119 | 0.1117 | 0.2488 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0245 | 0.367 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0084 | 0.0405 | 0.0901 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/BRSK protein kinase | 0.0084 | 0.0405 | 0.0056 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0084 | 0.0405 | 0.5 |
Loa Loa (eye worm) | 5'-AMP-activated protein kinase | 0.0119 | 0.1117 | 0.179 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2580 nM | Displacement of [125I-His5,D-Tyr6]GnRH from human cloned GnRH receptor transfected in COS7 cells | ChEMBL. | 17561404 |
Ki (binding) | = 2580 nM | Displacement of [125I-His5,D-Tyr6]GnRH from human cloned GnRH receptor transfected in COS7 cells | ChEMBL. | 17561404 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.