Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Giardia lamblia | 5-AMP-activated protein kinase, beta-1 subunit | 0.0115 | 0.2488 | 0.2182 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Loa Loa (eye worm) | 5'-AMP-activated protein kinase | 0.0115 | 0.2488 | 0.179 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Echinococcus multilocularis | serine:threonine kinase SAD 1 | 0.0081 | 0.0901 | 0.0901 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0237 | 0.8172 | 0.8172 |
Leishmania major | hypothetical protein, conserved | 0.0115 | 0.2488 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Brugia malayi | loechrig isoform VII | 0.0237 | 0.8172 | 0.8002 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Echinococcus granulosus | serine:threonine kinase SAD 1 | 0.0081 | 0.0901 | 0.0901 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0115 | 0.2488 | 1 |
Echinococcus multilocularis | AMPK beta subunit | 0.0115 | 0.2488 | 0.2488 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0081 | 0.0901 | 0.0901 |
Loa Loa (eye worm) | CAMK/CAMKL/BRSK protein kinase | 0.0081 | 0.0901 | 0.0056 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Brugia malayi | putative serine/threonine kinase SADA gamma | 0.0081 | 0.0901 | 0.0056 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0276 | 1 | 1 |
Plasmodium falciparum | serine/threonine protein kinase KIN | 0.0081 | 0.0901 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0081 | 0.0901 | 0.0901 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0276 | 1 | 1 |
Toxoplasma gondii | histone kinase SNF1, putative | 0.0081 | 0.0901 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0081 | 0.0901 | 0.5 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0115 | 0.2488 | 0.179 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0081 | 0.0901 | 0.0901 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0115 | 0.2488 | 0.179 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0237 | 0.8172 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0216 | 0.7177 | 0.7177 |
Onchocerca volvulus | Alicorn homolog | 0.01 | 0.1808 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Schistosoma mansoni | protein kinase subunit beta | 0.0115 | 0.2488 | 0.2488 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0081 | 0.0901 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0081 | 0.0901 | 0.5 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0115 | 0.2488 | 1 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0115 | 0.2488 | 1 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0237 | 0.8172 | 0.8172 |
Echinococcus granulosus | AMPK beta subunit | 0.0115 | 0.2488 | 0.2488 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0081 | 0.0901 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0901 | 0.0056 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0237 | 0.8172 | 0.8172 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0237 | 0.8172 | 0.8002 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0276 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 75 uM | Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms incubated for 48 hrs by alamar blue assay | ChEMBL. | 27060763 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 1 | ChEMBL. | 17960927 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 3 | ChEMBL. | 17960927 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 4 | ChEMBL. | 17960927 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 5 | ChEMBL. | 17960927 |
MIC (functional) | > 50 ug ml-1 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus NCTC 6571 | ChEMBL. | 17960927 |
MIC (functional) | > 50 ug ml-1 | Antibacterial activity against Mycobacterium fortuitum NCTC 10394 | ChEMBL. | 17960927 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Aspergillus niger IMI 149007 | ChEMBL. | 17960927 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans NCPF 3179 | ChEMBL. | 17960927 |
MIC (functional) | > 50 ug ml-1 | Antibacterial activity against Streptococcus faecalis NCTC 775 | ChEMBL. | 17960927 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans NCPF 3179 | ChEMBL. | 17960927 |
MIC (functional) | = 64 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 2 | ChEMBL. | 17960927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.