Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.854 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 7.167 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 7.4949 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | nM | Inhibitory activity of the compound against recombinant lc dihydrofolate reductase(in 50 microM dihydrofolic acid); ND=Not determined | ChEMBL. | 8691474 |
IC50 (binding) | nM | Inhibitory activity of the compound against recombinant sf dihydrofolate reductase(in 50 microM dihydrofolic acid); ND=Not determined | ChEMBL. | 8691474 |
IC50 (binding) | 0 nM | Inhibitory activity of the compound against recombinant ec dihydrofolate reductase(in 50 microM dihydrofolic acid); ND=Not determined | ChEMBL. | 8691474 |
IC50 (binding) | 0 nM | Inhibitory activity of the compound against recombinant sf dihydrofolate reductase(in 50 microM dihydrofolic acid); ND=Not determined | ChEMBL. | 8691474 |
IC50 (binding) | 0 nM | Inhibitory activity of the compound against recombinant lc dihydrofolate reductase(in 50 microM dihydrofolic acid); ND=Not determined | ChEMBL. | 8691474 |
IC50 (binding) | = 32 nM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 32 nM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 35 nM | Inhibitory activity of the compound against Toxoplasma gondii dihydrofolate reductase (in 50 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 35 nM | Inhibitory activity of the compound against Toxoplasma gondii dihydrofolate reductase (in 50 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 68 nM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 68 nM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 140 nM | Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 140 nM | Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 700 nM | Inhibitory activity against recombinant human dihydrofolate reductase(in 50 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 700 nM | Inhibitory activity against recombinant human dihydrofolate reductase(in 50 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 0.032 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.032 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.068 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.068 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.14 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.14 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.8539 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 7.1675 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 7.4949 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Selectivity ratio (binding) | 0 | Selectivity ratio is defined as IC50 human DHFR/IC50 ecDHFR; ND=Not determined | ChEMBL. | 8691474 |
Selectivity ratio (binding) | 0 | Selectivity ratio is defined as IC50 human DHFR/IC50 sfDHFR; ND=Not determined | ChEMBL. | 8691474 |
Selectivity ratio (binding) | 0 | Selectivity ratio is defined as IC50 human DHFR/IC50 lcDHFR; ND=Not determined | ChEMBL. | 8691474 |
Selectivity ratio (binding) | = 2.1 | Selectivity ratio is defined as IC50 rlDHFR/IC50 pcDHFR | ChEMBL. | 8691474 |
Selectivity ratio (binding) | = 4.4 | Selectivity ratio is defined as IC50 rlDHFR/IC50 tgDHFR | ChEMBL. | 8691474 |
Selectivity ratio (binding) | = 20 | Selectivity ratio is defined as IC50 human DHFR/IC50 tgDHFR | ChEMBL. | 8691474 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.