Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Monoamine oxidase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase B | 520 aa | 539 aa | 22.3 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase B | 520 aa | 531 aa | 23.2 % |
Brugia malayi | amine oxidase, flavin-containing family protein | Monoamine oxidase B | 520 aa | 479 aa | 21.7 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase B | 520 aa | 538 aa | 21.0 % |
Onchocerca volvulus | Mitochondrial fission process protein 1 homolog | Monoamine oxidase B | 520 aa | 469 aa | 22.0 % |
Dictyostelium discoideum | amine oxidase | Monoamine oxidase B | 520 aa | 489 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0025 | 0.0554 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0025 | 0.0554 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0025 | 0.0554 | 1 |
Echinococcus multilocularis | 0.0025 | 0.0554 | 1 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0.0554 | 0.1541 |
Schistosoma mansoni | amine oxidase | 0.0025 | 0.0554 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0025 | 0.0554 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0025 | 0.0554 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0245 | 0.6779 | 1 |
Schistosoma mansoni | amine oxidase | 0.0025 | 0.0554 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0245 | 0.6779 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0025 | 0.0554 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0025 | 0.0554 | 0.0554 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0025 | 0.0554 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0911 | 1 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0133 | 0.3594 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0025 | 0.0554 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0554 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0025 | 0.0554 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0025 | 0.0554 | 1 |
Leishmania major | ferric reductase, putative | 0.0133 | 0.3594 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0245 | 0.6779 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0.9284 | 1 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0133 | 0.3594 | 1 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0911 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0554 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0025 | 0.0554 | 1 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0133 | 0.3594 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0025 | 0.0554 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0025 | 0.0554 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0025 | 0.0554 | 0.0554 |
Leishmania major | UDP-galactopyranose mutase | 0.0025 | 0.0554 | 0.1541 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0025 | 0.0554 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0.0554 | 0.1541 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.3023 | 0.3967 |
Mycobacterium ulcerans | monoamine oxidase | 0.0025 | 0.0554 | 0.0554 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0025 | 0.0554 | 0.0554 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0025 | 0.0554 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.51 uM | Inhibition of MAOB in rat brain mitochondria | ChEMBL. | 17910428 |
IC50 (binding) | = 2.51 uM | Inhibition of MAOB in rat brain mitochondria | ChEMBL. | 17910428 |
Inhibition (binding) | = 0 % | Inhibition of MAOA in rat brain mitochondria at 10 uM | ChEMBL. | 17910428 |
Inhibition (binding) | = 0 % | Inhibition of MAOA in rat brain mitochondria at 10 uM | ChEMBL. | 17910428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.