Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Aph-1 protein, putative | 0.407 | 0.3805 | 1 |
Brugia malayi | Presenilin family protein | 0.044 | 0.0278 | 0.0278 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.044 | 0.0278 | 0.0221 |
Echinococcus multilocularis | presenilin | 0.044 | 0.0278 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0059 | 0.0059 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.044 | 0.0278 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.044 | 0.0278 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.044 | 0.0278 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0413 | 0.0252 | 0.0252 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 1.0446 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0215 | 0.0059 | 0.0059 |
Echinococcus granulosus | presenilin | 0.044 | 0.0278 | 0.0221 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.407 | 0.3805 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 1.0446 | 1 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.044 | 0.0278 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0413 | 0.0252 | 0.0194 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 1.0446 | 1 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0413 | 0.0252 | 0.0252 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.407 | 0.3805 | 1 |
Brugia malayi | hypothetical protein | 0.0215 | 0.0059 | 0.0059 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.044 | 0.0278 | 0.5 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0413 | 0.0252 | 0.0194 |
Toxoplasma gondii | hypothetical protein | 0.0154 | 0 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 1.0446 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (ADMET) | > 200 ug ml-1 | Toxicity assessed as hemolytic activity against mouse erythrocyte | ChEMBL. | 17827021 |
IC50 (functional) | = 0.89 ug ml-1 | Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 0.89 ug ml-1 | Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 1 ug ml-1 | Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 1 ug ml-1 | Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (ADMET) | = 1.34 ug ml-1 | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (ADMET) | = 1.34 ug ml-1 | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 1.43 ug ml-1 | Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 1.43 ug ml-1 | Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 2.52 ug ml-1 | Cytotoxicity against human SF295 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 2.52 ug ml-1 | Cytotoxicity against human SF295 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 2.99 ug ml-1 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | = 2.99 ug ml-1 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (ADMET) | = 3.08 ug ml-1 | Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (ADMET) | = 3.08 ug ml-1 | Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay | ChEMBL. | 17827021 |
IC50 (functional) | > 4000 uM | Trypanocidal activity against Trypanosoma cruzi Y blood stream trypomastigotes after 24 hrs | ChEMBL. | 18378461 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17827021 | |
Mus musculus | ChEMBL23 | 17827021 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.