Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | membrane bound transcription factor site 1 | 0.0444 | 1 | 0.5 |
Schistosoma mansoni | site-1 peptidase (S08 family) | 0.0444 | 1 | 1 |
Onchocerca volvulus | 0.0444 | 1 | 0.5 | |
Echinococcus granulosus | membrane bound transcription factor site 1 | 0.0444 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 22.8 mg Kg-1 | Anticonvulsant activity against MES-induced seizure in ip dosed C57B/6 mouse by MES test | ChEMBL. | 17761423 |
ED50 (functional) | = 22.8 mg Kg-1 | Anticonvulsant activity against MES-induced seizure in ip dosed C57B/6 mouse by MES test | ChEMBL. | 17761423 |
Ratio TD50/ED50 (functional) | = 4 | Protective index, ratio of TD50 for C57B/6 mouse by rotarod test to ED50 for C57B/6 mouse by MES test | ChEMBL. | 17761423 |
TD50 (ADMET) | = 91.3 mg Kg-1 | Neurotoxicity in ip dosed C57B/6 mouse after 30 mins by rotarod test | ChEMBL. | 17761423 |
TD50 (ADMET) | = 91.3 mg Kg-1 | Neurotoxicity in ip dosed C57B/6 mouse after 30 mins by rotarod test | ChEMBL. | 17761423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.