Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1151 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.1151 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.1151 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.1151 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.1151 | 1 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.1151 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0913 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.1151 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1151 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | < -4 | Displacement of [3H]spiperone from dopamine D2 receptor in rat brain | ChEMBL. | 17869521 |
Ki (binding) | < -4 | Displacement of [3H]ketanserin from 5HT2A receptor in rat brain | ChEMBL. | 17869521 |
Log Ki (binding) | < 4 | Displacement of [3H]spiperone from dopamine D2 receptor in rat brain | ChEMBL. | 17869521 |
Log Ki (binding) | < 4 | Displacement of [3H]ketanserin from 5HT2A receptor in rat brain | ChEMBL. | 17869521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.