Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | abcb9, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Brugia malayi | ABC transporter family protein | 0.003 | 0.0027 | 0.5 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.003 | 0.0027 | 1 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.003 | 0.0027 | 0.5 |
Entamoeba histolytica | P-glycoprotein-2 | 0.003 | 0.0027 | 0.5 |
Schistosoma mansoni | smdr2 | 0.003 | 0.0027 | 0.5 |
Entamoeba histolytica | P-glycoprotein-1 | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.003 | 0.0027 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0027 | 0.5 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0945 | 0.2778 | 0.5 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Entamoeba histolytica | P-glycoprotein-5 | 0.003 | 0.0027 | 0.5 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | thymidine phosphorylase | 0.3348 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | abcb9, putative | 0.003 | 0.0027 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.003 | 0.0027 | 0.0027 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0029 | 0.0026 | 0.0026 |
Leishmania major | p-glycoprotein | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | ABC transporter, putative | 0.003 | 0.0027 | 1 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.3348 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0945 | 0.2778 | 0.2759 |
Entamoeba histolytica | P-glycoprotein-2 | 0.003 | 0.0027 | 0.5 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0027 | 1 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.003 | 0.0027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0027 | 1 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.5 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.003 | 0.0027 | 0.0027 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0029 | 0.0026 | 0.0026 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | abcb9, putative | 0.003 | 0.0027 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0027 | 0.5 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | ABC transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.3348 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Brugia malayi | multidrug resistance protein 3 | 0.003 | 0.0027 | 0.5 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.003 | 0.0027 | 0.5 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | taga, putative | 0.003 | 0.0027 | 1 |
Onchocerca volvulus | 0.003 | 0.0027 | 0.5 | |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.003 | 0.0027 | 0.0027 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of 12-hLO | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO2 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 12-hLO | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO2 | ChEMBL. | 17869117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.