Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | multidrug resistance protein 1, putative | 0.003 | 0.0027 | 0.5 |
Entamoeba histolytica | P-glycoprotein-1 | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Brugia malayi | ABC transporter family protein | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | abcb9, putative | 0.003 | 0.0027 | 1 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.003 | 0.0027 | 0.5 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Entamoeba histolytica | P-glycoprotein-2 | 0.003 | 0.0027 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.003 | 0.0027 | 0.5 |
Schistosoma mansoni | smdr2 | 0.003 | 0.0027 | 0.5 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.003 | 0.0027 | 1 |
Entamoeba histolytica | P-glycoprotein-2 | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | ABC transporter, putative | 0.003 | 0.0027 | 1 |
Leishmania major | p-glycoprotein | 0.003 | 0.0027 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.3348 | 1 | 1 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0945 | 0.2778 | 0.2759 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.003 | 0.0027 | 1 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0945 | 0.2778 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.3348 | 1 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0029 | 0.0026 | 0.0026 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.003 | 0.0027 | 0.0027 |
Entamoeba histolytica | P-glycoprotein-5 | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.003 | 0.0027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0029 | 0.0026 | 0.0026 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.003 | 0.0027 | 0.0027 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.003 | 0.0027 | 0.0027 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0027 | 1 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.003 | 0.0027 | 0.0027 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Onchocerca volvulus | 0.003 | 0.0027 | 0.5 | |
Trichomonas vaginalis | taga, putative | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0027 | 0.5 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.003 | 0.0027 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0027 | 0.5 |
Trichomonas vaginalis | ABC transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Brugia malayi | multidrug resistance protein 3 | 0.003 | 0.0027 | 0.5 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.003 | 0.0027 | 0.5 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.003 | 0.0027 | 0.0027 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.003 | 0.0027 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.003 | 0.0027 | 1 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.3348 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of 12-hLO | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO2 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 12-hLO | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO2 | ChEMBL. | 17869117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.