Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0003 | 0.005 |
Echinococcus granulosus | muscleblind protein | 0.0112 | 0.0247 | 0.0247 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | RNA binding protein | 0.0041 | 0.0003 | 0.0124 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0097 | 0.0049 |
Brugia malayi | RNA binding protein | 0.0041 | 0.0003 | 0.0124 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.0097 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0041 | 0.0003 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0247 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.0097 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0112 | 0.0247 | 0.0247 |
Schistosoma mansoni | hypothetical protein | 0.0216 | 0.0611 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0111 | 0.0247 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0097 | 0.1589 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0041 | 0.0003 | 0.0124 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0097 | 0.0049 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.014 | 0.0347 | 0.0347 |
Brugia malayi | Muscleblind-like protein | 0.0112 | 0.0247 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0112 | 0.0247 | 0.0247 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0003 | 0.005 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0824 | 0.2722 | 1 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0824 | 0.2722 | 0.2686 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.2918 | 1 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.014 | 0.0347 | 0.0347 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0041 | 0.0003 | 0.0124 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0041 | 0.0003 | 0.0003 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.0097 | 0.0049 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.2918 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0041 | 0.0003 | 0.0003 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.2918 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0003 | 0.005 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0097 | 0.0049 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0111 | 0.0247 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.0097 | 0.0097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0003 | 0.005 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0111 | 0.0247 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0247 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0041 | 0.0003 | 0.0124 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.0824 | 0.2722 | 0.2686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0003 | 0.005 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0097 | 0.1589 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of 12-hLO | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO2 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 12-hLO | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO2 | ChEMBL. | 17869117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.