Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0711 | 0.0651 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.4439 | 0.5396 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0.0064 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.1014 | 0.0453 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.7379 | 0.7362 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.4439 | 0.5381 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0191 | 0.0127 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.7379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.7379 | 0.7362 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.7379 | 0.7362 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.7379 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.4722 | 0.6015 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.1014 | 0.0453 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.4722 | 0.6015 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0082 | 0.1363 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0003 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.4439 | 0.5 | |
Trypanosoma brucei | ISWI complex protein | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.7379 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0.0064 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.7379 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4722 | 0.4688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.006 | 0.8876 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.7379 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.7379 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4722 | 0.4688 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4439 | 0.4403 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26 uM | Inhibition of HCV NS5B RdRp | ChEMBL. | 17258458 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.