Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | insulin-like growth factor 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0172 | 1 | 1 |
Echinococcus granulosus | insulin receptor | 0.0158 | 0.8591 | 0.8586 |
Brugia malayi | Protein kinase domain containing protein | 0.0087 | 0.1575 | 0.1575 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0172 | 1 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0158 | 0.8591 | 0.8586 |
Onchocerca volvulus | Putative GMP reductase | 0.0072 | 0 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0072 | 0.0031 | 0.0031 |
Trypanosoma brucei | GMP reductase | 0.0172 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0162 | 0.8984 | 0.8869 |
Brugia malayi | Protein kinase domain containing protein | 0.0158 | 0.8591 | 0.8591 |
Leishmania major | guanosine monophosphate reductase | 0.0172 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0172 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0172 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0172 | 1 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0158 | 0.8591 | 0.8591 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0162 | 0.8984 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0172 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.8591 | 0.8586 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0172 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0172 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0172 | 1 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0172 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0172 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0158 | 0.8591 | 0.8586 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0172 | 1 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0162 | 0.8984 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1448 | 0.1448 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0172 | 1 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0172 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.8591 | 0.8586 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0158 | 0.8591 | 0.8586 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0072 | 0.0031 | 0.0031 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.009 | 0.1873 | 0.0954 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0172 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.