Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0211 | 0.1765 | 0.168 |
Entamoeba histolytica | kinesin, putative | 0.0138 | 0.107 | 0.5 |
Brugia malayi | Sodium:solute symporter family protein | 0.0038 | 0.0102 | 0.0244 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0211 | 0.1765 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0105 | 0.0747 | 0.2822 |
Brugia malayi | GH02984p | 0.0038 | 0.0102 | 0.0244 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0138 | 0.107 | 0.2556 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.1777 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0102 | 0.0244 |
Echinococcus multilocularis | thymidylate synthase | 0.0105 | 0.0747 | 0.0652 |
Echinococcus multilocularis | Protein lozenge | 0.0058 | 0.0295 | 0.0195 |
Brugia malayi | thymidylate synthase | 0.0105 | 0.0747 | 0.1785 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.1777 | 1 |
Onchocerca volvulus | 0.0105 | 0.0747 | 0.1579 | |
Brugia malayi | hypothetical protein | 0.005 | 0.0218 | 0.052 |
Brugia malayi | dihydrofolate reductase family protein | 0.0211 | 0.1765 | 0.4215 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.0347 | 0.1464 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0211 | 0.1765 | 0.4215 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.1777 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0138 | 0.107 | 0.2556 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0058 | 0.0292 | 0.0192 |
Schistosoma mansoni | lozenge | 0.0058 | 0.0295 | 0.0226 |
Giardia lamblia | Kinesin-5 | 0.0138 | 0.107 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.1777 | 0.5 |
Loa Loa (eye worm) | runx1 | 0.0058 | 0.0295 | 0.0706 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.0347 | 0.0837 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0211 | 0.1765 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.0292 | 0.0222 |
Loa Loa (eye worm) | thymidylate synthase | 0.0105 | 0.0747 | 0.1785 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.4188 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.0347 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.4188 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0138 | 0.107 | 0.1131 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0105 | 0.0747 | 0.3423 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0102 | 0.0244 |
Brugia malayi | Dihydrofolate reductase | 0.0211 | 0.1765 | 0.4215 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0347 | 0.0286 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0138 | 0.107 | 0.5781 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0211 | 0.1765 | 0.168 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0058 | 0.0292 | 0.0192 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0105 | 0.0747 | 0.0753 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.0347 | 0.0248 |
Echinococcus multilocularis | kinesin family 1 | 0.1066 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0212 | 0.1777 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0927 | 0.8667 | 1 |
Onchocerca volvulus | 0.0462 | 0.4188 | 1 | |
Brugia malayi | hypothetical protein | 0.0462 | 0.4188 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0211 | 0.1765 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0347 | 0.0286 |
Echinococcus granulosus | thymidylate synthase | 0.0105 | 0.0747 | 0.0652 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0218 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0211 | 0.1765 | 0.1942 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0211 | 0.1765 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.1777 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 42.62 % | Hypotensive activity in anaesthetized cat assessed as blood pressure fall at 2 umol/kg, iv | ChEMBL. | 17234413 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.