Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0215 | 0.1704 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0306 | 0.2611 | 0.6004 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0107 | 0.0641 | 0.0561 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0216 | 0.1717 | 0.6771 |
Echinococcus multilocularis | Protein lozenge | 0.0059 | 0.0169 | 0.0004 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0216 | 0.1717 | 0.6771 |
Brugia malayi | Kinesin motor domain containing protein | 0.0137 | 0.0938 | 0.2051 |
Echinococcus granulosus | dihydrofolate reductase | 0.0215 | 0.1704 | 0.1565 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.0391 | 0.0732 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.0982 | 0.3871 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0299 | 0.2536 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.0223 | 0.0068 |
Echinococcus granulosus | thymidylate synthase | 0.0107 | 0.0641 | 0.0484 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.0982 | 0.3281 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0051 | 0.0087 | 0.0344 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0216 | 0.1717 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.1139 | 0.6186 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.0223 | 0.0976 |
Schistosoma mansoni | dihydrofolate reductase | 0.0215 | 0.1704 | 0.1815 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.2611 | 0.2884 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0299 | 0.2536 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0215 | 0.1704 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.0223 | 0.0059 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0299 | 0.2536 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.0223 | 0.0059 |
Echinococcus multilocularis | snurportin 1 | 0.0306 | 0.2611 | 0.2487 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0216 | 0.1717 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0216 | 0.1717 | 1 |
Schistosoma mansoni | lozenge | 0.0059 | 0.0169 | 0.0004 |
Brugia malayi | Dihydrofolate reductase | 0.0215 | 0.1704 | 0.3898 |
Schistosoma mansoni | kinesin eg-5 | 0.0137 | 0.0938 | 0.0912 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.0223 | 0.0068 |
Echinococcus granulosus | snurportin 1 | 0.0306 | 0.2611 | 0.2487 |
Schistosoma mansoni | hypothetical protein | 0.0918 | 0.8647 | 1 |
Onchocerca volvulus | 0.0471 | 0.4236 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.4236 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0091 | 0.0358 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.0087 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.1139 | 0.6506 |
Echinococcus multilocularis | kinesin family 1 | 0.1055 | 1 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0137 | 0.0938 | 0.1892 |
Brugia malayi | hypothetical protein | 0.0471 | 0.4236 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0137 | 0.0938 | 0.5296 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.0982 | 0.3871 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0215 | 0.1704 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.0223 | 0.0837 |
Mycobacterium ulcerans | thymidylate synthase | 0.0107 | 0.0641 | 0.2822 |
Echinococcus multilocularis | thymidylate synthase | 0.0107 | 0.0641 | 0.0484 |
Brugia malayi | dihydrofolate reductase family protein | 0.0215 | 0.1704 | 0.3898 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0215 | 0.1704 | 0.3776 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0215 | 0.1704 | 0.1565 |
Giardia lamblia | Kinesin-5 | 0.0137 | 0.0938 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.4236 | 1 |
Brugia malayi | thymidylate synthase | 0.0107 | 0.0641 | 0.1334 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0299 | 0.2536 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0107 | 0.0641 | 0.1161 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0215 | 0.1704 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0107 | 0.0641 | 0.3423 |
Entamoeba histolytica | kinesin, putative | 0.0137 | 0.0938 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0216 | 0.1717 | 0.646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.