Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0.1084 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0042 | 0.1084 | 0.1084 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0.1084 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 1 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0.1084 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.1084 | 0.1084 | |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0047 | 0.1487 | 0.1487 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0042 | 0.1084 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0047 | 0.1487 | 0.1487 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.005 | 0.1778 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0042 | 0.1084 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1084 | 0.1084 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0042 | 0.1084 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0077 | 0.4121 | 0.3406 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.1084 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.7588 | 0.8549 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0042 | 0.1084 | 0.6098 |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0.1084 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.1084 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0047 | 0.1487 | 0.0529 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0042 | 0.1084 | 0.6098 |
Brugia malayi | Matrixin family protein | 0.0051 | 0.1858 | 0.1858 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0042 | 0.1084 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0051 | 0.1858 | 0.1017 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0.1084 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.6281 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8692 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0077 | 0.4121 | 0.3406 |
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0.1084 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.2 uM | Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide | ChEMBL. | 17433673 |
IC50 (binding) | = 5.2 uM | Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide | ChEMBL. | 17433673 |
IC50 (binding) | = 5.2 uM | Inhibition of pig kidney microsomes aminopeptidase N preincubated for 30 mins | ChEMBL. | 19683842 |
IC50 (binding) | = 13 uM | Inhibition of MMP2 after 30 mins | ChEMBL. | 17433673 |
IC50 (binding) | = 13 uM | Inhibition of MMP2 after 30 mins | ChEMBL. | 17433673 |
Ratio IC50 (binding) | = 0.4 | Ratio of IC50 for microsomal aminopeptidase to IC50 for MMP2 | ChEMBL. | 17433673 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.