Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1279 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0152 | 0.1196 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0106 | 0.0448 | 0.1364 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0152 | 0.1196 | 1 |
Loa Loa (eye worm) | aminopeptidase N | 0.0152 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.003 | 0.003 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0152 | 0.1196 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0515 | 0.7105 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 0.464 | 0.464 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.6238 | 0.6238 |
Brugia malayi | Peptidase family M1 containing protein | 0.0515 | 0.7105 | 0.6969 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1124 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0152 | 0.1196 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0515 | 0.7105 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0106 | 0.0448 | 0.0174 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.033 | 0.033 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0106 | 0.0448 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0152 | 0.1196 | 0.5 |
Brugia malayi | hypothetical protein | 0.0152 | 0.1196 | 0.0783 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0694 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0106 | 0.0448 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0152 | 0.1196 | 0.0783 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.003 | 0.003 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0152 | 0.1196 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0152 | 0.1196 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0515 | 0.7105 | 1 | |
Toxoplasma gondii | peptidase family M13 protein | 0.0106 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.033 | 0.033 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0152 | 0.1196 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0448 | 0.0448 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1124 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0152 | 0.1196 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0152 | 0.1196 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.003 | 0.003 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.003 | 0.003 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1124 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0152 | 0.1196 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0152 | 0.1196 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0152 | 0.1196 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1279 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0152 | 0.1196 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.003 | 0.003 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0152 | 0.1196 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0417 | 0.5507 | 0.5507 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0152 | 0.1196 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Anti-uterotrophic effect (functional) | = 28.8 | Anti-uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 125 ug dose | ChEMBL. | 6492074 |
Anti-uterotrophic effect (functional) | = 36.6 | Anti-uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 25 ug dose | ChEMBL. | 6492074 |
Anti-uterotrophic effect (functional) | = 39.2 | Anti-uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 5 ug dose | ChEMBL. | 6492074 |
Anti-uterotrophic effect (functional) | = 40 | Anti-uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 1 ug dose | ChEMBL. | 6492074 |
Anti-uterotrophic effect (functional) | = 28.8 | Anti-uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 125 ug dose | ChEMBL. | 6492074 |
Anti-uterotrophic effect (functional) | = 36.6 | Anti-uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 25 ug dose | ChEMBL. | 6492074 |
Anti-uterotrophic effect (functional) | = 39.2 | Anti-uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 5 ug dose | ChEMBL. | 6492074 |
Anti-uterotrophic effect (functional) | = 40 | Anti-uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 1 ug dose | ChEMBL. | 6492074 |
Change of body weight (functional) | = 0 % | Change in body weight of DMBA-induced mammary carcinoma tumour bearing rats at 5.1 mg dose | ChEMBL. | 6492074 |
Change of body weight (functional) | = 2 % | Change in body weight of DMBA-induced mammary carcinoma tumour bearing rats at 1.7 mg dose | ChEMBL. | 6492074 |
Change of tumor area (functional) | = -44 % | Change in DMBA-induced mammary carcinoma tumor area in rats at 5.1 mg dose; -44-333 | ChEMBL. | 6492074 |
Change of tumor area (functional) | = 9 % | Change in DMBA-induced mammary carcinoma tumor area in rats at 5.1 mg dose | ChEMBL. | 6492074 |
Change of tumor area (functional) | = 18 % | Change in DMBA-induced mammary carcinoma tumor area in rats at 5.1 mg dose | ChEMBL. | 6492074 |
Change of tumor area (functional) | = 318 % | Change in DMBA-induced mammary carcinoma tumor area in rats at 1.7 mg dose; 318-1054 | ChEMBL. | 6492074 |
Change of tumor area (functional) | = 577 % | Change in DMBA-induced mammary carcinoma tumor area in rats at 1.7 mg dose | ChEMBL. | 6492074 |
Complete remission (functional) | = 32 % | Complete remission (%) of DMBA-induced mammary carcinoma tumours in rats at 5.1 mg dose | ChEMBL. | 6492074 |
Inhibition (functional) | = 33 % | Percentage inhibition of uterotrophic activity at 1 ug dose | ChEMBL. | 6492074 |
Inhibition (functional) | = 33 % | Percentage inhibition of uterotrophic activity at 1 ug dose | ChEMBL. | 6492074 |
Inhibition (functional) | = 35 % | Percentage inhibition of uterotrophic activity at 5 ug dose | ChEMBL. | 6492074 |
Inhibition (functional) | = 35 % | Percentage inhibition of uterotrophic activity at 5 ug dose | ChEMBL. | 6492074 |
Inhibition (functional) | = 42 % | Percentage inhibition of uterotrophic activity at 25 ug dose | ChEMBL. | 6492074 |
Inhibition (functional) | = 42 % | Percentage inhibition of uterotrophic activity at 25 ug dose | ChEMBL. | 6492074 |
Inhibition (functional) | = 62 % | Percentage inhibition of uterotrophic activity at 125 ug dose | ChEMBL. | 6492074 |
Inhibition (functional) | = 62 % | Percentage inhibition of uterotrophic activity at 125 ug dose | ChEMBL. | 6492074 |
New tumors (functional) | = 37 | Formation of new DMBA-induced mammary carcinoma tumors in rats at 5.1 mg dose | ChEMBL. | 6492074 |
New tumors (functional) | = 38 | Formation of new DMBA-induced mammary carcinoma tumors in rats at 1.7 mg dose | ChEMBL. | 6492074 |
No. of tumors (functional) | = 29 | Number of DMBA-induced mammary carcinoma tumors in rats at 1.7 mg dose | ChEMBL. | 6492074 |
No. of tumors (functional) | = 37 | Number of DMBA-induced mammary carcinoma tumors in rats at 5.1 mg dose | ChEMBL. | 6492074 |
Partial remission (functional) | = 6 % | Partial remission (%) of DMBA-induced mammary carcinoma tumours in rats at 1.7 mg dose | ChEMBL. | 6492074 |
Partial remission (functional) | = 10 % | Partial remission (%) of DMBA-induced mammary carcinoma tumours in rats at 5.1 mg dose | ChEMBL. | 6492074 |
Progressed tumors (functional) | = 39 % | Percent progressive DMBA-induced mammary carcinoma tumours in rats at 5.1 mg dose | ChEMBL. | 6492074 |
Progressed tumors (functional) | = 70 % | Percent progressive DMBA-induced mammary carcinoma tumours in rats at 1.7 mg dose | ChEMBL. | 6492074 |
Static tumors (functional) | = 15 % | Percent unchanged DMBA-induced mammary carcinoma tumours in rats at 1.7 mg dose | ChEMBL. | 6492074 |
Static tumors (functional) | = 19 % | Percent unchanged DMBA-induced mammary carcinoma tumours in rats at 5.1 mg dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 13.7 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 1 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 14.6 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 5 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 16.1 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 25 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 20.9 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 125 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 13.7 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 1 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 14.6 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 5 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 16.1 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 25 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 20.9 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 125 ug dose | ChEMBL. | 6492074 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.