Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) | Human herpesvirus 5 DNA polymerase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0092 | 0.0346 | 0.0475 |
Onchocerca volvulus | 0.027 | 0.3998 | 0.3783 | |
Echinococcus granulosus | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Trypanosoma cruzi | hexokinase, putative | 0.0431 | 0.7289 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0563 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1265 | 0.0952 |
Onchocerca volvulus | 0.0431 | 0.7289 | 0.7192 | |
Echinococcus multilocularis | glycogen phosphorylase | 0.0563 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0133 | 0.119 | 0.0874 |
Toxoplasma gondii | hexokinase | 0.0431 | 0.7289 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0431 | 0.7289 | 0.7192 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0563 | 1 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.027 | 0.3998 | 0.3783 |
Trypanosoma brucei | hexokinase | 0.0431 | 0.7289 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0431 | 0.7289 | 0.7192 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Trypanosoma brucei | hexokinase | 0.0431 | 0.7289 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0563 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0243 | 0.3448 | 0.3213 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0563 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0431 | 0.7289 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0243 | 0.3448 | 0.5 |
Brugia malayi | hexokinase type II | 0.0137 | 0.1265 | 0.0952 |
Echinococcus multilocularis | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Treponema pallidum | hexokinase (hxk) | 0.0431 | 0.7289 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0563 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0431 | 0.7289 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0431 | 0.7289 | 0.7192 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0563 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0563 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.4481 | 0.4283 |
Echinococcus multilocularis | hexokinase type 2 | 0.0431 | 0.7289 | 0.7192 |
Echinococcus granulosus | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Schistosoma mansoni | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0563 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0563 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0431 | 0.7289 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0243 | 0.3448 | 0.3213 |
Entamoeba histolytica | hexokinase 1 | 0.0431 | 0.7289 | 0.7192 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0243 | 0.3448 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0563 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0563 | 1 | 1 |
Onchocerca volvulus | 0.0431 | 0.7289 | 0.7192 | |
Loa Loa (eye worm) | hexokinase | 0.027 | 0.3998 | 0.3783 |
Plasmodium vivax | hexokinase, putative | 0.0431 | 0.7289 | 1 |
Brugia malayi | Hexokinase family protein | 0.027 | 0.3998 | 0.3783 |
Brugia malayi | Hexokinase family protein | 0.0431 | 0.7289 | 0.7192 |
Brugia malayi | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Trypanosoma cruzi | hexokinase, putative | 0.0431 | 0.7289 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0133 | 0.119 | 0.0874 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0243 | 0.3448 | 0.3213 |
Onchocerca volvulus | 0.0431 | 0.7289 | 0.7192 | |
Loa Loa (eye worm) | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1265 | 0.0952 |
Echinococcus granulosus | glycogen phosphorylase | 0.0563 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0431 | 0.7289 | 0.7192 |
Trypanosoma brucei | hexokinase, putative | 0.0431 | 0.7289 | 1 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0243 | 0.3448 | 0.3213 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 5000 nM | Antiviral activity against HCMV Davis in HFF cells by plaque reduction assay | ChEMBL. | 17434304 |
IC50 (binding) | = 8400 nM | Inhibition of HCMV DNA polymerase by scintillation proximity assay | ChEMBL. | 17434304 |
IC50 (binding) | = 8400 nM | Inhibition of HCMV DNA polymerase by scintillation proximity assay | ChEMBL. | 17434304 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.