Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase-activated protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Brugia malayi | map kinase activated protein kinase protein 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma japonicum | ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase-activated protein kinase 2 | 370 aa | 303 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0398 | 0.8311 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0398 | 0.8311 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1015 | 0.1124 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.1015 | 0.1124 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0257 | 0.0528 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0217 | 0.3917 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0398 | 0.8311 | 1 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0217 | 0.3917 | 0.4511 |
Trichomonas vaginalis | set domain proteins, putative | 0.0467 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0257 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0257 | 0.0238 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0059 | 0.0053 | 0.0135 |
Brugia malayi | Pre-SET motif family protein | 0.041 | 0.8618 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0398 | 0.8311 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0398 | 0.8311 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.041 | 0.8618 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.1015 | 0.1124 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0398 | 0.8311 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0217 | 0.3917 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0398 | 0.8311 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0398 | 0.8311 | 0.5 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0217 | 0.3917 | 1 |
Brugia malayi | map kinase activated protein kinase protein 2 | 0.0217 | 0.3917 | 0.4511 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.1015 | 0.1124 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.