Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Aph-1 protein, putative | 0.437 | 0.3566 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.3021 | 0.2298 | 0.2298 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.3218 | 0.2484 | 1 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.3218 | 0.2484 | 0.6965 |
Brugia malayi | hypothetical protein | 0.1569 | 0.0933 | 0.0438 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 1.1214 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 1.1214 | 1 | 1 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0909 | 0.0313 | 0.0877 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.2226 | 0.155 | 0.1089 |
Echinococcus multilocularis | Nicastrin | 0.1569 | 0.0933 | 0.0933 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.3021 | 0.2298 | 0.2298 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.3021 | 0.2298 | 0.1877 |
Echinococcus granulosus | presenilin | 0.3218 | 0.2484 | 0.2484 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 1.1214 | 1 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 1.1214 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.437 | 0.3566 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.3218 | 0.2484 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.3218 | 0.2484 | 1 |
Echinococcus multilocularis | presenilin | 0.3218 | 0.2484 | 0.2484 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.3218 | 0.2484 | 0.6965 |
Schistosoma mansoni | hypothetical protein | 0.1569 | 0.0933 | 0.0728 |
Echinococcus granulosus | Nicastrin | 0.1569 | 0.0933 | 0.0933 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.3218 | 0.2484 | 0.6965 |
Loa Loa (eye worm) | hypothetical protein | 0.1754 | 0.1107 | 0.079 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.437 | 0.3566 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.3218 | 0.2484 | 0.2314 |
Echinococcus multilocularis | Nicastrin | 0.1569 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | presenilin spe-4 | 0.1127 | 0.0518 | 0.018 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.3218 | 0.2484 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1127 | 0.0518 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.3021 | 0.2298 | 0.2023 |
Brugia malayi | hypothetical protein | 0.1569 | 0.0933 | 0.0438 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.3218 | 0.2484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1569 | 0.0933 | 0.061 |
Brugia malayi | Presenilin family protein | 0.3218 | 0.2484 | 0.2073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | Antifungal activity against Erysiphe graminis f. sp. tritici at 100 mg/mL relative to control | ChEMBL. | 17656087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.