Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | presenilin enhancer 2 | 0.2944 | 0.2035 | 0.1342 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.3137 | 0.2203 | 0.1889 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.3137 | 0.2203 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.3137 | 0.2203 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.3137 | 0.2203 | 0.5 |
Echinococcus granulosus | presenilin | 0.3137 | 0.2203 | 0.1524 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 1.2078 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.4706 | 0.3571 | 1 |
Echinococcus multilocularis | presenilin | 0.3137 | 0.2203 | 0.1524 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.2944 | 0.2035 | 0.2035 |
Brugia malayi | hypothetical protein | 0.1529 | 0.08 | 0.0392 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 1.2078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1224 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 1.2078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2278 | 0.1454 | 0.1454 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.2891 | 0.1988 | 0.1633 |
Toxoplasma gondii | hypothetical protein | 0.1099 | 0.0425 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.4706 | 0.3571 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1529 | 0.08 | 0.08 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.3137 | 0.2203 | 1 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.3137 | 0.2203 | 0.5892 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 1.2078 | 1 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.2944 | 0.2035 | 0.1342 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.3137 | 0.2203 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1529 | 0.08 | 0.0431 |
Loa Loa (eye worm) | presenilin spe-4 | 0.1099 | 0.0425 | 0.0425 |
Brugia malayi | Presenilin family protein | 0.3137 | 0.2203 | 0.1856 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.4706 | 0.3571 | 1 |
Brugia malayi | hypothetical protein | 0.1529 | 0.08 | 0.0392 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.2944 | 0.2035 | 0.1681 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of TNFalpha-induced necroptosis in FADD-deficient Jurkat T cells | ChEMBL. | 17270434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.