Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor NHR-88 | 0.0037 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0174 | 0.0174 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0.0174 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0828 | 1 | 1 |
Trypanosoma brucei | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0325 | 0.3752 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0037 | 0.0174 | 0.0174 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0.0174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0174 | 0.0174 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0037 | 0.0174 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0037 | 0.0174 | 0.0174 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0037 | 0.0174 | 0.0174 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0.0174 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0174 | 0.0174 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0325 | 0.3752 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0174 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0037 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0174 | 0.0174 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0174 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0341 | 0.3944 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0174 | 0.0174 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0.0174 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0174 | 0.0174 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0.0174 | 1 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.0325 | 0.3752 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0.0174 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0174 | 0.0174 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0174 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0174 | 0.0174 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0174 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0174 | 0.0174 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0.0174 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0.0174 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0174 | 0.0174 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0.0174 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0.0174 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0.0174 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0174 | 0.0174 |
Leishmania major | malonyl-coa decarboxylase-like protein | 0.0325 | 0.3752 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0.0174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0174 | 0.0174 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0174 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0174 | 0.0174 |
Wolbachia endosymbiont of Brugia malayi | malonyl-CoA decarboxylase | 0.0828 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0.0174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | ecdysteroid receptor | 0.0341 | 0.3944 | 0.3944 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0174 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0174 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0.0174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.3944 | 0.3944 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | steroid hormone receptor | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0037 | 0.0174 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0174 | 0.0174 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 100 % | Antifungal activity against Erysiphe graminis f. sp. tritici at 100 mg/mL relative to control | ChEMBL. | 17656087 |
LogP | = 4.12 | Partition coefficient, log P of the compound by chromatographic hydrophobicity method | ChEMBL. | 17656087 |
Solubility | = 0.48 ug ml-1 | Aqueous solubility of the compound at pH 7.0 | ChEMBL. | 17656087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.