Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | presenilin | 0.0216 | 0.0398 | 0.0316 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.3611 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0084 | 0.0084 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0322 | 0.0697 | 0.0697 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.1407 | 0.3766 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0203 | 0.036 | 0.036 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0203 | 0.036 | 0.0279 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0216 | 0.0398 | 1 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0118 | 0.0118 | 0.0034 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0216 | 0.0398 | 0.0316 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0216 | 0.0398 | 1 |
Brugia malayi | Presenilin family protein | 0.0216 | 0.0398 | 0.0398 |
Echinococcus multilocularis | presenilin | 0.0216 | 0.0398 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.0504 | 0.0504 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0216 | 0.0398 | 0.5 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0203 | 0.036 | 0.036 |
Trypanosoma brucei | Aph-1 protein, putative | 0.1407 | 0.3766 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0216 | 0.0398 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.3611 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.1407 | 0.3766 | 1 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0203 | 0.036 | 0.0279 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0216 | 0.0398 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.3611 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0076 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.3611 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0172 | 0.0172 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.