Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | insulin-like growth factor 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.215 | 0.2138 |
Brugia malayi | Protein kinase domain containing protein | 0.0885 | 0.9415 | 0.9414 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0158 | 0.1012 | 0.0998 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0885 | 0.9415 | 0.9414 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0158 | 0.1012 | 0.0998 |
Echinococcus multilocularis | insulin receptor | 0.0158 | 0.1012 | 0.0998 |
Echinococcus granulosus | insulin receptor | 0.0158 | 0.1012 | 0.0998 |
Loa Loa (eye worm) | hypothetical protein | 0.0935 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.1012 | 0.1075 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0015 | 0.0016 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0935 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0885 | 0.9415 | 0.9414 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0935 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0885 | 0.9415 | 0.9414 |
Onchocerca volvulus | Deterin homolog | 0.0935 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.018 | 0.0165 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0257 | 0.215 | 0.2283 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0257 | 0.215 | 0.2138 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0257 | 0.215 | 0.2138 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0885 | 0.9415 | 0.9254 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0257 | 0.215 | 0.2138 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.1012 | 0.1075 |
Brugia malayi | Protein kinase domain containing protein | 0.0158 | 0.1012 | 0.0998 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0885 | 0.9415 | 0.9414 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0015 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0257 | 0.215 | 0.2283 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0885 | 0.9415 | 0.9414 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0015 | 0.0016 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0158 | 0.1012 | 0.0998 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0257 | 0.215 | 0.2283 |
Brugia malayi | Protein kinase domain containing protein | 0.0087 | 0.0195 | 0.018 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0885 | 0.9415 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 79 nM | Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assay | ChEMBL. | 17689078 |
IC50 (binding) | = 79 nM | Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assay | ChEMBL. | 17689078 |
IC50 (binding) | = 104 nM | Inhibition IGF1R phosphorylation in human MiaPaCa2 cells | ChEMBL. | 17689078 |
IC50 (binding) | = 104 nM | Inhibition IGF1R phosphorylation in human MiaPaCa2 cells | ChEMBL. | 17689078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.