Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.3403 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0123 | 0.0245 | 0.0484 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0049 | 0.0049 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0137 | 0.0286 | 1 |
Brugia malayi | hypothetical protein | 0.2648 | 0.7754 | 0.7754 |
Trypanosoma brucei | Prostaglandin E synthase | 0.2648 | 0.7754 | 0.7746 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.2648 | 0.7754 | 0.7746 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0123 | 0.0245 | 0.0484 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0165 | 0.0165 |
Mycobacterium ulcerans | hypothetical protein | 0.1486 | 0.4297 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0049 | 0.0049 |
Echinococcus multilocularis | 0.0056 | 0.0043 | 0.0043 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0413 | 0.0413 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0123 | 0.0245 | 0.0484 |
Echinococcus multilocularis | 0.3403 | 1 | 1 | |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.2648 | 0.7754 | 0.7746 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0165 | 0.0165 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.2648 | 0.7754 | 0.7746 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0123 | 0.0245 | 0.0484 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0054 | 0.0038 | 0.0038 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0165 | 0.0165 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0137 | 0.0286 | 0.058 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0054 | 0.0038 | 0.0038 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.0049 | 0.0049 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0413 | 0.0413 |
Mycobacterium tuberculosis | Probable reductase | 0.0123 | 0.0245 | 0.0484 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0162 | 0.0162 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 0.5 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.3403 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 0.5 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.0049 | 0.0049 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.3403 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0054 | 0.0038 | 0.0038 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0049 | 0.0049 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0162 | 0.0162 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0137 | 0.0286 | 0.058 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0054 | 0.0038 | 0.0038 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0137 | 0.0286 | 0.058 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.3403 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.1486 | 0.4297 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.0049 | 0.001 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.3403 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0413 | 0.0376 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.2648 | 0.7754 | 0.7746 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Onchocerca volvulus | 0.2648 | 0.7754 | 0.5 | |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.0049 | 0.0049 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0413 | 0.0413 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.3403 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0165 | 0.0165 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0413 | 0.0413 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0162 | 0.0162 |
Toxoplasma gondii | prostaglandin-E synthase | 0.2648 | 0.7754 | 0.7746 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0123 | 0.0245 | 0.0484 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | Inhibition of partially purified EGFR tyrosine kinase from human A431 cells | ChEMBL. | 17869510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.