Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.1 nM | Inhibition of cholesterol synthesis in rat hepatocyte | ChEMBL. | 17574412 |
IC50 (binding) | = 0.3 nM | Inhibition of HMG-CoA reductase | ChEMBL. | 17574412 |
IC50 (binding) | = 0.3 nM | Inhibition of HMG-CoA reductase | ChEMBL. | 17574412 |
IC50 (functional) | = 684 nM | Inhibition of cholesterol synthesis in rat myocyte | ChEMBL. | 17574412 |
Inhibition (functional) | = -45 % | Inhibition of acute cholesterol synthesis in mouse at 1 mg/kg | ChEMBL. | 17574412 |
Inhibition (functional) | = -45 % | Inhibition of acute cholesterol synthesis in mouse at 1 mg/kg | ChEMBL. | 17574412 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.