Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0074 | 0.0086 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.1045 | 0.6532 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0245 | 0.1145 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0.1045 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0074 | 0.0086 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.1045 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.156 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0245 | 0.0282 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.1045 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1438 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0074 | 0.0086 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0074 | 0.0086 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0245 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0245 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1731 | 0.1998 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0245 | 0.0171 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0245 | 0.0171 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0245 | 0.0171 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0074 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1316 | 0.8354 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0245 | 0.0282 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.1045 | 0.6532 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.156 | 0.1497 |
Schistosoma mansoni | kinesin eg-5 | 0.0032 | 0.1045 | 0.1206 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0074 | 0.0086 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1438 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.1045 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.1045 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8663 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.156 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1731 | 0.1998 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.156 | 0.1497 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 13 nM | Mitotic arrest in human A2780 cells assessed as G2/M block after 16 hrs | ChEMBL. | 17804233 |
EC50 (functional) | = 13 nM | Mitotic arrest in human A2780 cells assessed as G2/M block after 16 hrs | ChEMBL. | 17804233 |
IC50 (binding) | = 1.8 nM | Inhibition of kinesin spindle protein | ChEMBL. | 17804233 |
IC50 (binding) | = 1.8 nM | Inhibition of kinesin spindle protein | ChEMBL. | 17804233 |
IC50 | = 3300 nM | Inhibition of hERG expressed in HEK cells | ChEMBL. | 17804233 |
IC50 | = 3300 nM | Inhibition of hERG expressed in HEK cells | ChEMBL. | 17804233 |
Ratio IC50 (functional) | = 1.5 | Ratio of IC50 for KB-V-1 cells to IC50 for KB-3-1 cells after 16 hrs | ChEMBL. | 17804233 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17804233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.