Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0142 | 0.4279 | 0.4279 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0299 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.486 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.4279 | 0.4198 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0074 | 0.1841 | 0.5 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0028 | 0.0139 | 0.0139 |
Echinococcus multilocularis | hypothetical protein | 0.0098 | 0.2686 | 1 |
Schistosoma mansoni | DNA polymerase gamma | 0.0098 | 0.2686 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0082 | 0.2117 | 0.2117 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0044 | 0.0733 | 0.5 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0098 | 0.2686 | 1 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0054 | 0.1104 | 0.3791 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0158 | 0.486 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0299 | 1 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0666 | 0.0666 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0666 | 0.0534 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.089 | 1 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0046 | 0.0803 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0028 | 0.0139 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0299 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0139 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.1 | 0.0873 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0054 | 0.1104 | 0.3791 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0028 | 0.0139 | 0.0139 |
Brugia malayi | DNA polymerase I family protein | 0.0098 | 0.2686 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.2117 | 0.7764 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0666 | 0.0534 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0028 | 0.0139 | 0.5 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0054 | 0.1104 | 0.3791 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0666 | 0.0534 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.4279 | 0.4198 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2686 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.