Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.486 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.4279 | 0.4198 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.4279 | 0.4279 |
Schistosoma mansoni | DNA polymerase gamma | 0.0095 | 0.2686 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.008 | 0.2117 | 0.2117 |
Echinococcus multilocularis | hypothetical protein | 0.0095 | 0.2686 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0027 | 0.0139 | 0.0139 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0073 | 0.1841 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.486 | 0.5 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0053 | 0.1104 | 0.3791 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0095 | 0.2686 | 1 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0043 | 0.0733 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 1 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0027 | 0.0139 | 0.5 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0666 | 0.0534 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0045 | 0.0803 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.089 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0666 | 0.0666 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0292 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.1 | 0.0873 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0139 | 0.5 |
Brugia malayi | DNA polymerase I family protein | 0.0095 | 0.2686 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0027 | 0.0139 | 0.0139 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0053 | 0.1104 | 0.3791 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.4279 | 0.4198 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0666 | 0.0534 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0053 | 0.1104 | 0.3791 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0027 | 0.0139 | 0.5 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0666 | 0.0534 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2117 | 0.7764 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.2686 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.