Detailed information for compound 46069

Basic information

Technical information
  • TDR Targets ID: 46069
  • Name: (1S,3R,4R,5R)-1-[4-(4-chlorophenyl)butoxy]-3, 4-dihydroxy-5-[(E)-3-(4-hydroxyphenyl)prop-2- enoyl]oxycyclohexane-1-carboxylic acid
  • MW: 504.957 | Formula: C26H29ClO8
  • H donors: 4 H acceptors: 6 LogP: 3.77 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(O[C@@H]1C[C@@](OCCCCc2ccc(cc2)Cl)(C[C@H]([C@H]1O)O)C(=O)O)/C=C/c1ccc(cc1)O
  • InChi: 1S/C26H29ClO8/c27-19-9-4-17(5-10-19)3-1-2-14-34-26(25(32)33)15-21(29)24(31)22(16-26)35-23(30)13-8-18-6-11-20(28)12-7-18/h4-13,21-22,24,28-29,31H,1-3,14-16H2,(H,32,33)/b13-8+/t21-,22-,24-,26+/m1/s1
  • InChiKey: RNXLLTKDJTXNAP-GSTBBQIISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S,3R,4R,5R)-1-[4-(4-chlorophenyl)butoxy]-3,4-dihydroxy-5-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-cyclohexanecarboxylic acid
  • (1S,3R,4R,5R)-1-[4-(4-chlorophenyl)butoxy]-3,4-dihydroxy-5-[(E)-3-(4-hydroxyphenyl)-1-oxoallyloxy]cyclohexanecarboxylic acid
  • (1S,3R,4R,5R)-1-[4-(4-chlorophenyl)butoxy]-3,4-dihydroxy-5-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-cyclohexane-1-carboxylic acid
  • (1S,3R,4R,5R)-1-[4-(4-chlorophenyl)butoxy]-3,4-dihydroxy-5-[(E)-3-(4-hydroxyphenyl)acryloyl]oxy-cyclohexanecarboxylic acid
  • (1S,3R,4R,5R)-1-[4-(4-chlorophenyl)butoxy]-3,4-dihydroxy-5-[(E)-3-(4-hydroxyphenyl)-1-oxoprop-2-enoxy]-1-cyclohexanecarboxylic acid
  • (1S,3R,4R,5R)-1-[4-(4-chlorophenyl)butoxy]-3,4-dihydroxy-5-[(E)-3-(4-hydroxyphenyl)acryloyl]oxy-cyclohexane-1-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0652 0.4662 1
Echinococcus multilocularis orexin receptor type 2 0.0131 0.085 0.1083
Schistosoma mansoni neuropeptide receptor 0.0131 0.085 0.1824
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0028 0.0061
Onchocerca volvulus Neuropeptide F receptor homolog 0.0131 0.085 0.085
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.085 0.1083
Plasmodium vivax telomerase reverse transcriptase, putative 0.0377 0.2655 0.5
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus granulosus g-protein coupled receptor 0.0131 0.085 0.1083
Schistosoma mansoni neuropeptide f receptor 76f 0.0131 0.085 0.1824
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0131 0.085 0.1083
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0206 0.0263
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0131 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Onchocerca volvulus 0.0131 0.085 0.085
Schistosoma mansoni myosin xvIII 0.0131 0.085 0.1824
Echinococcus granulosus neuropeptide s receptor 0.0131 0.085 0.1083
Echinococcus granulosus G protein coupled receptor 139 0.0131 0.085 0.1083
Echinococcus granulosus neuropeptide receptor 0.0131 0.085 0.1083
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.085 0.1083
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.085 0.1083
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0472 0.3349 0.7184
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0131 0.085 0.1174
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.085 0.1083
Schistosoma mansoni opsin-like receptor 0.0131 0.085 0.1824
Schistosoma mansoni biogenic amine (5HT) receptor 0.0131 0.085 0.1824
Brugia malayi Cytochrome P450 family protein 0.0018 0.0028 0.0039
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni hypothetical protein 0.0131 0.085 0.1824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.085 0.1083
Echinococcus granulosus neuropeptide FF receptor 2 0.0131 0.085 0.1083
Schistosoma mansoni amine GPCR 0.0131 0.085 0.1824
Echinococcus granulosus alpha 1A adrenergic receptor 0.0131 0.085 0.1083
Onchocerca volvulus 0.0131 0.085 0.085
Onchocerca volvulus 0.0131 0.085 0.085
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Brugia malayi Cytochrome P450 family protein 0.0018 0.0028 0.0039
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0379 0.0483
Echinococcus multilocularis serotonin receptor 0.0652 0.4662 0.5941
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0131 0.085 0.1824
Echinococcus multilocularis g protein coupled receptor 0.0131 0.085 0.1083
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.085 0.1083
Echinococcus granulosus g protein coupled receptor 0.0131 0.085 0.1083
Echinococcus granulosus biogenic amine 5HT receptor 0.0652 0.4662 0.5941
Schistosoma mansoni biogenic amine receptor 0.0131 0.085 0.1824
Echinococcus multilocularis somatostatin receptor 0.0131 0.085 0.1083
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0131 0.085 0.1083
Giardia lamblia Telomerase catalytic subunit 0.0377 0.2655 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0131 0.085 0.1083
Schistosoma mansoni opsin-like receptor 0.0131 0.085 0.1824
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0131 0.085 0.1083
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.085 0.1083
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0131 0.085 0.1174
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0131 0.085 0.1824
Echinococcus granulosus orexin receptor type 2 0.0131 0.085 0.1083
Echinococcus granulosus g protein coupled receptor 0.0131 0.085 0.1083
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Loa Loa (eye worm) hypothetical protein 0.0652 0.4662 1
Onchocerca volvulus 0.0131 0.085 0.085
Echinococcus multilocularis G-protein coupled receptor, putative 0.0131 0.085 0.1083
Echinococcus multilocularis serotonin receptor 0.0652 0.4662 0.5941
Schistosoma mansoni amine GPCR 0.0131 0.085 0.1824
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0186 0.5
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus granulosus sex peptide receptor 0.0131 0.085 0.1083
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni biogenic amine receptor 0.0131 0.085 0.1824
Loa Loa (eye worm) melatonin receptor type 1A 0.0131 0.085 0.1824
Echinococcus granulosus somatostatin receptor 0.0131 0.085 0.1083
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.085 0.1824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.085 0.1083
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.085 0.1083
Brugia malayi larval opioid receptor 0.0131 0.085 0.1174
Loa Loa (eye worm) hypothetical protein 0.0472 0.3349 0.7184
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Onchocerca volvulus 0.0131 0.085 0.085
Brugia malayi Serotonin receptor 0.0662 0.4737 0.6544
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0131 0.085 0.1824
Echinococcus multilocularis g-protein coupled receptor 0.0131 0.085 0.1083
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.085 0.1083
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.085 0.1083
Onchocerca volvulus 0.0131 0.085 0.085
Echinococcus granulosus biogenic amine 5HT receptor 0.0131 0.085 0.1083
Echinococcus granulosus g protein coupled receptor 0.0131 0.085 0.1083
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.085 0.1083
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0131 0.085 0.1083
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0347 0.0744
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Brugia malayi AKH receptor 0.0131 0.085 0.1174
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0131 0.085 0.1083
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0379 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni opsin-like receptor 0.0131 0.085 0.1824
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.085 0.1824
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.085 0.1824
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0131 0.085 0.1083
Brugia malayi GnHR receptor homolog 0.0131 0.085 0.1174
Onchocerca volvulus 0.0131 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0235 0.0504
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Onchocerca volvulus 0.0131 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0131 0.085 0.1824
Brugia malayi putative neuropeptide receptor NPR1 0.0131 0.085 0.1174
Echinococcus multilocularis sex peptide receptor 0.0131 0.085 0.1083
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.085 0.1083
Echinococcus granulosus 7TM GPCR rhodopsin 0.0131 0.085 0.1083
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0379 0.1336
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0131 0.085 0.1083
Loa Loa (eye worm) TYRA-2 protein 0.0131 0.085 0.1824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Brugia malayi Dopamine receptor protein 1 0.0131 0.085 0.1174
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0028 0.0061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.085 0.1083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.085 0.1083
Echinococcus granulosus fmrfamide receptor 0.0131 0.085 0.1083
Brugia malayi follicle stimulating hormone receptor 0.0131 0.085 0.1174
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0472 0.3349 0.7184
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Onchocerca volvulus 0.0131 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus granulosus tm gpcr rhodopsin 0.1088 0.7847 1
Onchocerca volvulus 0.0131 0.085 0.085
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.085 0.1083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1088 0.7847 1
Echinococcus granulosus dro:myosuppressin receptor 0.0131 0.085 0.1083
Brugia malayi Melatonin receptor type 1A 0.0131 0.085 0.1174
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.085 0.1824
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0186 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0131 0.085 0.1824
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.085 0.1083
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0131 0.085 0.1824
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0131 0.085 0.1824
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0206 0.0263
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.085 0.1083
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.085 0.1083
Echinococcus multilocularis G protein coupled receptor 139 0.0131 0.085 0.1083
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0131 0.085 0.1174
Echinococcus multilocularis g protein coupled receptor 0.0131 0.085 0.1083
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0131 0.085 0.1083
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0377 0.2655 1
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.085 0.1824
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.085 0.1824
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus granulosus neuropeptide receptor 0.0131 0.085 0.1083
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Schistosoma mansoni hypothetical protein 0.0131 0.085 0.1824
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Brugia malayi sulfakinin receptor protein 0.0131 0.085 0.1174
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.085 0.1824
Schistosoma mansoni biogenic amine receptor 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0037 0.0165 0.0354
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0131 0.085 0.1083
Schistosoma mansoni amine GPCR 0.0131 0.085 0.1824
Schistosoma mansoni amine GPCR 0.0513 0.3649 0.7827
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.085 0.1083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.085 0.1083
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0131 0.085 0.1083
Echinococcus multilocularis dro:myosuppressin receptor 0.0131 0.085 0.1083
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni alpha-1 adrenergic receptor 0.0131 0.085 0.1824
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0377 0.2655 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0131 0.085 0.1083
Schistosoma mansoni histamine h1 receptor 0.0131 0.085 0.1824
Schistosoma mansoni neuropeptide receptor 0.0131 0.085 0.1824
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0379 0.0814
Echinococcus multilocularis fmrfamide receptor 0.0131 0.085 0.1083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Toxoplasma gondii RNA-directed DNA polymerase 0.0377 0.2655 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.085 0.1083
Schistosoma mansoni biogenic amine (5HT) receptor 0.0652 0.4662 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Onchocerca volvulus 0.0131 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus multilocularis neuropeptide receptor 0.0131 0.085 0.1083
Brugia malayi Dopamine receptor protein 2 0.0131 0.085 0.1174
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.085 0.1824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.085 0.1083
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni adenoreceptor 0.0131 0.085 0.1824
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.085 0.1824
Onchocerca volvulus 0.0131 0.085 0.085
Echinococcus granulosus hypothetical protein 0.0928 0.6681 0.8514
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0235 0.0504
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.085 0.1824
Brugia malayi hypothetical protein 0.0131 0.085 0.1174
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0206 0.0443
Onchocerca volvulus 0.0131 0.085 0.085
Brugia malayi G protein-coupled receptor 0.0131 0.085 0.1174
Onchocerca volvulus 0.0131 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus multilocularis neuropeptide s receptor 0.0131 0.085 0.1083
Brugia malayi Dopamine receptor 0.0131 0.085 0.1174
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0131 0.085 0.1824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Brugia malayi G protein-coupled receptor F59B2.13 0.0131 0.085 0.1174
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0379 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0131 0.085 0.1083
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus granulosus allatostatin A receptor 0.0131 0.085 0.1083
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0028 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Echinococcus multilocularis allatostatin A receptor 0.0131 0.085 0.1083
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus multilocularis neuropeptide receptor 0.0131 0.085 0.1083
Brugia malayi Tachykinin-like peptides receptor 99D 0.0131 0.085 0.1174
Onchocerca volvulus 0.0131 0.085 0.085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Brugia malayi Serotonin receptor 0.0131 0.085 0.1174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Brugia malayi G-protein coupled receptor 0.0131 0.085 0.1174
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0131 0.085 0.1174
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Brugia malayi ORL1-like opioid receptor 0.0131 0.085 0.1174
Plasmodium falciparum telomerase reverse transcriptase 0.0377 0.2655 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.085 0.1083
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.085 0.1083
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0131 0.085 0.1824
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.085 0.1083
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.085 0.1824
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.085 0.1083
Schistosoma mansoni hypothetical protein 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0131 0.085 0.1083
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0206 0.0285
Brugia malayi G-protein coupled receptor 0.0131 0.085 0.1174
Echinococcus granulosus peptide allatostatin:somatostatin 0.0131 0.085 0.1083
Brugia malayi neuropeptide F receptor 0.0131 0.085 0.1174
Trypanosoma brucei telomerase reverse transcriptase 0.0377 0.2655 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0472 0.3349 0.4626
Echinococcus granulosus serotonin receptor 0.0131 0.085 0.1083
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.085 0.1083
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.085 0.1083
Brugia malayi RE15519p 0.0131 0.085 0.1174
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0379 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.085 0.1083
Echinococcus multilocularis g protein coupled receptor 0.0131 0.085 0.1083
Leishmania major telomerase reverse transcriptase, putative 0.0377 0.2655 1
Onchocerca volvulus 0.0131 0.085 0.085
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0131 0.085 0.1083
Schistosoma mansoni neuropeptide receptor 0.0131 0.085 0.1824
Brugia malayi Telomerase reverse transcriptase 0.1004 0.724 1
Echinococcus multilocularis conserved hypothetical protein 0.0797 0.5726 0.7296
Schistosoma mansoni growth hormone secretagogue receptor 0.0131 0.085 0.1824
Echinococcus multilocularis neuropeptide FF receptor 2 0.0131 0.085 0.1083
Echinococcus multilocularis fmrfamide receptor 0.0131 0.085 0.1083
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0379 0.0483
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0131 0.085 0.1083
Brugia malayi neuropeptide F receptor 0.0131 0.085 0.1174
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.085 0.1083
Brugia malayi putative neuropeptide receptor 0.0131 0.085 0.1174
Schistosoma mansoni neuropeptide receptor 0.0131 0.085 0.1824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.085 0.1824
Schistosoma mansoni hypothetical protein 0.0131 0.085 0.1824
Loa Loa (eye worm) hypothetical protein 0.0131 0.085 0.1824
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0379 0.0524
Onchocerca volvulus 0.0131 0.085 0.085
Schistosoma mansoni amine GPCR 0.0131 0.085 0.1824
Echinococcus multilocularis neuropeptide receptor A26 0.0131 0.085 0.1083

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 85 uM Inhibition glucose-6-phosphate hydrolysis in highly intact microsomal preparations obtained from livers of 20-h fasted rats. ChEMBL. 9003513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.