Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0338 | 0.0227 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.1994 | 0.3613 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.5118 | 1 | 1 |
Echinococcus multilocularis | presenilin | 0.0649 | 0.0862 | 0.0693 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.1994 | 0.3613 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0609 | 0.078 | 0.061 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0649 | 0.0862 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.5118 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0316 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.0182 | 0.0182 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.5118 | 1 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0649 | 0.0862 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0649 | 0.0862 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0609 | 0.078 | 0.078 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0649 | 0.0862 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0649 | 0.0862 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.1994 | 0.3613 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0338 | 0.0227 | 0.5 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0609 | 0.078 | 0.078 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0649 | 0.0862 | 0.0693 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0609 | 0.078 | 0.061 |
Brugia malayi | hypothetical protein | 0.0316 | 0.0182 | 0.0182 |
Brugia malayi | Presenilin family protein | 0.0649 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.5118 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0227 | 0 | 0.5 |
Echinococcus granulosus | presenilin | 0.0649 | 0.0862 | 0.0693 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.