Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0617 | 0.0777 | 0.0623 |
Brugia malayi | Presenilin family protein | 0.0617 | 0.0777 | 0.0777 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0617 | 0.0777 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0617 | 0.0777 | 1 |
Echinococcus granulosus | presenilin | 0.0617 | 0.0777 | 0.0623 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1003 | 0.1524 | 0.1383 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2095 | 0.3641 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.5378 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1003 | 0.1524 | 0.1383 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0579 | 0.0703 | 0.0548 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.5378 | 1 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0579 | 0.0703 | 0.0703 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0579 | 0.0703 | 0.0703 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.5378 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0301 | 0.0164 | 0.0164 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.5378 | 1 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0617 | 0.0777 | 0.5 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0579 | 0.0703 | 0.0548 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0617 | 0.0777 | 1 |
Echinococcus multilocularis | presenilin | 0.0617 | 0.0777 | 0.0623 |
Brugia malayi | hypothetical protein | 0.0301 | 0.0164 | 0.0164 |
Toxoplasma gondii | hypothetical protein | 0.0216 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.0164 | 0.0164 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2095 | 0.3641 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0617 | 0.0777 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.2095 | 0.3641 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.