Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.1581 | 1 | 0.5 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0601 | 0 | 0.5 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.0601 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.1581 | 1 | 0.5 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.1581 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | = 6.4 mg kg-1 | Optimal dose required for antitumor activity against P-388 murine leukemia cells in mice. | ChEMBL. | 6620304 |
Dose (functional) | = 6.4 mg kg-1 | Optimal dose required for antitumor activity against P-388 murine leukemia cells in mice. | ChEMBL. | 6620304 |
MED (functional) | = 1.6 mg kg-1 | Minimum effective dose required for antitumor activity against P-388 murine leukemia cells in mice. | ChEMBL. | 6620304 |
MED (functional) | = 1.6 mg kg-1 | Minimum effective dose required for antitumor activity against P-388 murine leukemia cells in mice. | ChEMBL. | 6620304 |
T/C (functional) | = 147 % | Maximum % T/C against P-388 murine leukemia cells in mice. | ChEMBL. | 6620304 |
T/C (functional) | = 147 % | Maximum % T/C against P-388 murine leukemia cells in mice. | ChEMBL. | 6620304 |
T/C (functional) | = 288 % | Maximum % T/C with mitomycin C against P-388 murine leukemia cells in mice. | ChEMBL. | 6620304 |
T/C (functional) | = 288 % | Maximum % T/C with mitomycin C against P-388 murine leukemia cells in mice. | ChEMBL. | 6620304 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.