Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.0271 | 0.0272 | 0.0106 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.0271 | 0.0272 | 1 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.2658 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0247 | 0.0174 | 0.5 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0271 | 0.0272 | 0.0272 |
Schistosoma mansoni | protein kinase | 0.0271 | 0.0272 | 0.0099 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0247 | 0.0174 | 0.0007 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2658 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0247 | 0.0174 | 0.0174 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0271 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.2658 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0247 | 0.0174 | 0.0174 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.2658 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0271 | 0.0272 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0271 | 0.0272 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0247 | 0.0174 | 0.0174 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.0271 | 0.0272 | 1 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.0271 | 0.0272 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0271 | 0.0272 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0271 | 0.0272 | 1 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.0271 | 0.0272 | 0.0106 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0247 | 0.0174 | 0.0174 |
Brugia malayi | MAP kinase sur-1 | 0.0247 | 0.0174 | 0.0007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.