Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.0262 | 0.0321 | 0.0321 |
Trichomonas vaginalis | STE family protein kinase | 0.0262 | 0.0321 | 1 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.2658 | 1 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0262 | 0.0321 | 0.0321 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.0262 | 0.0321 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0262 | 0.0321 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0262 | 0.0321 | 0.0321 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0182 | 0 | 0.5 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.0262 | 0.0321 | 0.0321 |
Trichomonas vaginalis | STE family protein kinase | 0.0262 | 0.0321 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0262 | 0.0321 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.0262 | 0.0321 | 1 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.2658 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0262 | 0.0321 | 0.0321 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2658 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.0262 | 0.0321 | 1 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.2658 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.1 uM | Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation | ChEMBL. | 17197180 |
IC50 (functional) | > 40 uM | Antiinflammatory activity in neutophils assessed as inhibition of oxygen radical generation | ChEMBL. | 17197180 |
IC50 (functional) | > 40 uM | Antiinflammatory activity in neutorphil assessed as inhibition of fMLP induced elastase release | ChEMBL. | 17197180 |
IC50 (functional) | > 100 uM | Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation | ChEMBL. | 17197180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.