Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0219 | 1 | 0.5 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0144 | 0.4674 | 0.4674 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0077 | 0 | 0.5 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0144 | 0.4674 | 0.8962 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0077 | 0 | 0.5 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0144 | 0.4674 | 0.8962 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0151 | 0.5215 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0144 | 0.4674 | 0.4674 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0151 | 0.5215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.4674 | 0.8962 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0219 | 1 | 0.5 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0219 | 1 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0219 | 1 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0219 | 1 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0219 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED20 (functional) | ~ 1 mg kg-1 | Dose required for hypotensive activity in anesthetized rat after intravenous administration | ChEMBL. | 6118439 |
ED20 (functional) | ~ 46.4 mg kg-1 | Dose required for antihypertensive activity in spontaneous hypertensive rats after oral administration | ChEMBL. | 6118439 |
ED50 (functional) | ~ 0.0464 mg kg-1 | Dose required for inhibition of isoproterenol-induced tachycardia in pithed rat after intravenous administration | ChEMBL. | 6118439 |
Relative potency (functional) | ~ 1 | Relative potency required for antihypertensive activity in spontaneous hypertensive rats after oral administration | ChEMBL. | 6118439 |
Relative potency (functional) | ~ 3 | Relative potency required for inhibition of isoproterenol-induced tachycardia in pithed rat after intravenous administration | ChEMBL. | 6118439 |
Relative potency (functional) | ~ 5.2 | Relative potency required for hypotensive activity in anesthetized rat | ChEMBL. | 6118439 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.