Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2439 | 1 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1101 | 0.3991 | 0.3483 |
Schistosoma mansoni | hypothetical protein | 0.0602 | 0.1749 | 0.1749 |
Echinococcus granulosus | carbonic anhydrase | 0.0602 | 0.1749 | 0.1052 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0602 | 0.1749 | 0.1749 |
Echinococcus multilocularis | carbonic anhydrase | 0.0602 | 0.1749 | 0.1052 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0713 | 0.2249 | 0.2249 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.0536 | 0.0536 |
Echinococcus granulosus | carbonic anhydrase II | 0.2439 | 1 | 1 |
Brugia malayi | cation channel family protein | 0.0745 | 0.2394 | 0.0781 |
Echinococcus multilocularis | carbonic anhydrase | 0.0602 | 0.1749 | 0.1052 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2439 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2439 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0713 | 0.2249 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 0.1749 | 0.1749 |
Schistosoma mansoni | hypothetical protein | 0.043 | 0.0977 | 0.0977 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0533 | 0.144 | 0.144 |
Toxoplasma gondii | hypothetical protein | 0.0602 | 0.1749 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2439 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0602 | 0.1749 | 0.1052 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1412 | 0.5386 | 0.4996 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.0475 | 0.0475 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2439 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0602 | 0.1749 | 0.1052 |
Loa Loa (eye worm) | hypothetical protein | 0.1101 | 0.3991 | 0.3991 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2439 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 0.1749 | 0.1749 |
Echinococcus granulosus | carbonic anhydrase | 0.0602 | 0.1749 | 0.1052 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0602 | 0.1749 | 0.1749 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2439 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0713 | 0.2249 | 0.1595 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1412 | 0.5386 | 0.4996 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0602 | 0.1749 | 0.1749 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1101 | 0.3991 | 0.3483 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2439 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0602 | 0.1749 | 0.1749 |
Schistosoma mansoni | ryanodine receptor related | 0.1743 | 0.6875 | 0.6875 |
Loa Loa (eye worm) | ryanodine receptor | 0.0411 | 0.0894 | 0.0894 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2439 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0602 | 0.1749 | 0.1749 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.1743 | 0.6875 | 0.6213 |
Plasmodium falciparum | carbonic anhydrase | 0.0602 | 0.1749 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.0651 | 0.1971 | 0.1971 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 0.1749 | 0.1749 |
Leishmania major | carbonic anhydrase-like protein | 0.2439 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 45.7 uM | Concentration giving 50% relaxation of the 30 mM KCL-induced contraction of rat aorta rings | ChEMBL. | 10780901 |
ED50 (functional) | = 145 uM | Inhibition of electrically stimulated contractions of guinea pig ileum segments. | ChEMBL. | 10780901 |
ND (functional) | 0 | Effect on Insulin secretion from rat pancreatic islets in the presence of 16.7 mM glucose at 10 uM; Not determined. | ChEMBL. | 10780901 |
RIS (functional) | = 94.2 % | Insulin secretion from rat pancreatic islets (RIS) in the presence of 16.7 mM glucose at 50 uM | ChEMBL. | 10780901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.