Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fatty acid desaturase, putative | 0.2536 | 1 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2321 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2536 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2321 | 0 | 0.5 |
Onchocerca volvulus | 0.2536 | 1 | 0.5 | |
Leishmania major | fatty-acid desaturase, putative | 0.2536 | 1 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.2321 | 0 | 0.5 |
Onchocerca volvulus | 0.2536 | 1 | 0.5 | |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2321 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 30.89 | Activity of alkaline phosphatase (ALP) tested in serum of rat when 18 microg/kg of compound was administered intramuscularly when compared to vehicle prednisone and estrone | ChEMBL. | 12467635 |
Ca2+ (functional) | = 46.94 % | Percentage content of calcium in femur tested in the compound using male ICR rats | ChEMBL. | 12467635 |
Ca2+ (functional) | = 1.99 mM l-1 | Activity tested for the content of calcium in serum of rat when 18 microg/kg of compound was administered intramuscularly when compared to prednisone and estrone | ChEMBL. | 12467635 |
Phosphor (functional) | = 23.48 % | Percentage content of phosphor in femur tested in the compound using male ICR rats when compared to prednisone | ChEMBL. | 12467635 |
Weight (functional) | = 35.83 g | Weight of rat body tested after intramuscular administration of 18 microg/kg of compound when compared to vehicle, predinsone | ChEMBL. | 12467635 |
Weight (functional) | = 24.9 mg | Weight of rat femur ash tested after intramuscular administration of 18 microg/kg of compound when compared to vehicle, predinsone, and estrone | ChEMBL. | 12467635 |
Weight (functional) | = 41.6799999999998 mg | Weight of rat femur tested after intramuscular administration of 18 microg/kg of compound when compared to vehicle, predinsone, and estrone | ChEMBL. | 12467635 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.