Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor 2 | 0.0606 | 0.3392 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0606 | 0.3392 | 0.3392 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0592 | 0.3041 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0861 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0861 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0743 | 0.6959 | 0.6959 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0606 | 0.3392 | 0.3392 |
Chlamydia trachomatis | glutamine binding protein | 0.0592 | 0.3041 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0743 | 0.6959 | 0.6959 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0606 | 0.3392 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0743 | 0.6959 | 0.6959 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0743 | 0.6959 | 0.6959 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0743 | 0.6959 | 0.6959 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0743 | 0.6959 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0592 | 0.3041 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0743 | 0.6959 | 0.6959 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0592 | 0.3041 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0743 | 0.6959 | 0.6959 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0743 | 0.6959 | 0.6959 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0606 | 0.3392 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0592 | 0.3041 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0592 | 0.3041 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0743 | 0.6959 | 0.6959 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0743 | 0.6959 | 0.6959 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0606 | 0.3392 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0606 | 0.3392 | 0.3392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 89 uM | Inhibitory activity of the compound against proliferation of murine leukemia (L1210) cells | ChEMBL. | 12031320 |
IC50 (functional) | = 89 uM | Inhibitory activity of the compound against proliferation of murine leukemia (L1210) cells | ChEMBL. | 12031320 |
IC50 (functional) | = 93 uM | Inhibitory activity of the compound against proliferation of human epidermoid carcinoma (A431) cells | ChEMBL. | 12031320 |
IC50 (functional) | = 93 uM | Inhibitory activity of the compound against proliferation of human epidermoid carcinoma (A431) cells | ChEMBL. | 12031320 |
Inhibition (functional) | NT 0 % | Anti-angiogenic activity wasassessed by inhibition of the vascular growth in the chick embryo chorioallantoic membrane (CAM assay) at 125 nM | ChEMBL. | 12031320 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.