Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 0.001 M | Inhibitory activity against cAMP phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 microM) and calmodulin (15 nM); Compound is insignificant. | ChEMBL. | 2544722 |
IC50 (binding) | > 0.001 M | Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant. | ChEMBL. | 2544722 |
IC50 (binding) | > 0.001 M | Inhibitory activity against cAMP phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 microM) and calmodulin (15 nM); Compound is insignificant. | ChEMBL. | 2544722 |
IC50 (binding) | > 0.001 M | Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant. | ChEMBL. | 2544722 |
IC50 (binding) | = 34 uM | Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE. | ChEMBL. | 2544722 |
IC50 (binding) | = 34 uM | Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE. | ChEMBL. | 2544722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.