Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.2031 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.2031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2031 | 1 | 1 |
Echinococcus multilocularis | tryptophan hydroxylase | 0.1506 | 0.4721 | 0.5 |
Echinococcus granulosus | tryptophan hydroxylase | 0.1506 | 0.4721 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1506 | 0.4721 | 0.4721 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.2031 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 15 % | Ability to displace [3H]-GR 113808 from 5-hydroxytryptamine 4 receptor at concentration of 10e-8 M in guinea pig | ChEMBL. | 12502367 |
Inhibition (binding) | = 15 % | Ability to displace [3H]-GR 113808 from 5-hydroxytryptamine 4 receptor at concentration of 10e-8 M in guinea pig | ChEMBL. | 12502367 |
Inhibition (binding) | = 100 % | Ability to displace [3H]-GR 113808 from 5-hydroxytryptamine 4 receptor at concentration of 10e-6 M in guinea pig | ChEMBL. | 12502367 |
Inhibition (binding) | = 100 % | Ability to displace [3H]-GR 113808 from 5-hydroxytryptamine 4 receptor at concentration of 10e-6 M in guinea pig | ChEMBL. | 12502367 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.