Detailed view for EgrG_000069500

Basic information

TDR Targets ID: 580560
Echinococcus granulosus, tryptophan hydroxylase
Source Database / ID:  GeneDB

pI: 5.8269 | Length (AA): 422 | MW (Da): 48357 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00351   Biopterin-dependent aromatic amino acid hydroxylase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016714   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0009072   aromatic amino acid family metabolic process  
GO:0055114   oxidation reduction  

Metabolic Pathways

Tryptophan metabolism (KEGG)
Global map (KEGG)
Serotonergic synapse (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 400 5den (A) 52 450 46.00 0 1 1.51627 -0.61
66 408 4v06 (A) 149 489 59.00 0 1 1.6132 -1.23
68 357 5tpg (A) 105 394 63.00 0 1 1.4901 -1.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132520)

Species Accession Gene Product
Caenorhabditis elegans CELE_ZK1290.2   Protein TPH-1, isoform A
Drosophila melanogaster Dmel_CG9122   Tryptophan hydroxylase
Echinococcus granulosus EgrG_000069500   tryptophan hydroxylase
Echinococcus multilocularis EmuJ_000069500   tryptophan hydroxylase
Homo sapiens ENSG00000139287   tryptophan hydroxylase 2
Homo sapiens 7166   tryptophan hydroxylase 1
Loa Loa (eye worm) LOAG_01930   hypothetical protein
Mus musculus ENSMUSG00000006764   tryptophan hydroxylase 2
Mus musculus ENSMUSG00000040046   tryptophan hydroxylase 1
Schmidtea mediterranea mk4.006406.03   Tph

Essentiality

EgrG_000069500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK1290.2 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens tryptophan hydroxylase 1 Compounds References
Homo sapiens tryptophan hydroxylase 2 Compounds References
Rattus norvegicus Tryptophan 5-monooxygenase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
1.4327 0.6633 1
0.0529 0.6489 0.6489
0.0761 0.3013 0.3013
0.2304 0.7938 0.7936
0.0362 0.4037 0.5114
0.0761 0.3013 0.3013
0.3057 0.63 0.6974
0.0529 0.577 0.5767
1.4327 0.6633 1
0.0529 0.5651 0.6652
0.1624 0.2861 0.2861
0.5307 0.4473 0.5021
0.0529 0.3048 0.3641
0.0529 0.3908 0.3908
1.4327 0.6633 1
0.0442 0.3777 0.3777
0.0529 0.518 0.518
1.4327 0.6633 1
0.0217 0.7668 1
0.0857 0.4244 0.4244
0.0529 0.2763 1
0.1506 0.4721 0.5
0.0512 0.2706 1
0.2409 0.549 1
0.5877 0.6849 0.7108
0.0529 0.5459 1
0.0761 0.3013 0.3013
0.2291 0.5377 1
0.0814 0.462 0.5
0.2291 0.5377 1
1.4327 0.6633 1
0.0129 0.259 0.3298
0.0761 0.3013 0.3013
0.0471 0.4483 0.4483
0.0761 0.3013 0.3013
0.3515 0.4582 0.5117
0.0529 0.2572 0.2564
1.4327 0.6633 1
0.0139 0.2562 0.3276
0.0153 0.3138 0.5758
0.0137 0.2579 0.3199
0.0529 0.3152 1
0.0761 0.3013 0.3013
0.0529 0.577 0.5767
0.2304 0.7938 0.7936
0.0761 0.3013 0.3013
0.0217 0.737 1
0.0529 0.6312 1
0.0529 0.2827 0.2786
0.0761 0.3013 0.3013
0.0512 0.2706 1
0.0761 0.3013 0.3013
0.2409 0.549 1
0.0529 0.2849 0.4142

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EgrG_000069500 (Echinococcus granulosus), tryptophan hydroxylase
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