Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 207 aa | 30.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | amine GPCR | 0.0339 | 0.6593 | 0.6593 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0377 | 0.782 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 0.2345 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 0.2345 | 0.2345 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 0.2345 | 0.2345 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0.2345 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 0.2345 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0445 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0445 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0377 | 0.782 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 0.2345 | 0.2345 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 0.2345 | 0.2345 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 0.2345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.782 | 0.782 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1867 | 0.1867 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0445 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0377 | 0.782 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0445 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0445 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0377 | 0.782 | 0.7153 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.033 nM | Inhibition of L1210 cultured murine leukemia cell growth | ChEMBL. | 3112397 |
IC50 (functional) | = 0.033 nM | Inhibition of L1210 cultured murine leukemia cell growth | ChEMBL. | 3112397 |
IC50 (binding) | = 32 nM | Inhibition of dihydrofolate reductase(DHFR) from L1210/R81 cells | ChEMBL. | 3112397 |
IC50 (binding) | = 32 nM | Inhibition of dihydrofolate reductase(DHFR) from L1210/R81 cells | ChEMBL. | 3112397 |
IC50 (functional) | = 93 nM | Inhibition of L1210/R81 murine leukemia cell growth | ChEMBL. | 3112397 |
IC50 (functional) | = 93 nM | Inhibition of L1210/R81 murine leukemia cell growth | ChEMBL. | 3112397 |
Resistance (binding) | = 2800 | Fold resistance of the compound calculated by dividing the IC50(L1210/R81) by the IC50(L1210) | ChEMBL. | 3112397 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 3112397 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.