Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0946 | 0.2339 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0802 | 0.1681 | 0.0784 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0802 | 0.1682 | 0.0785 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0802 | 0.1681 | 0.2178 |
Loa Loa (eye worm) | ryanodine receptor | 0.098 | 0.2495 | 0.4255 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0946 | 0.2339 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0802 | 0.1681 | 0.2178 |
Leishmania major | hypothetical protein, conserved | 0.0643 | 0.0956 | 0.5 |
Schistosoma mansoni | ryanodine receptor related | 0.2622 | 1 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0619 | 0.0847 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.1656 | 0.5586 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1656 | 0.5586 | 0.7236 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1656 | 0.5586 | 0.7236 |
Loa Loa (eye worm) | hypothetical protein | 0.0499 | 0.0299 | 0.0175 |
Echinococcus granulosus | ryanodine receptor 44f | 0.2123 | 0.772 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.2123 | 0.772 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Cytotoxicity in the presence of thymidine and hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | > 100 uM | Cytotoxicity in the absence of thymidine and presence of hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | > 100 uM | Cytotoxicity in the absence of hypoxanthine and presence of thymidine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | > 100 uM | Cytotoxicity in the absence of thymidine and hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | > 100 uM | Cytotoxicity in the presence of thymidine and hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | > 100 uM | Cytotoxicity in the absence of thymidine and presence of hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | > 100 uM | Cytotoxicity in the absence of hypoxanthine and presence of thymidine against CCRF-CEM cell line | ChEMBL. | 10888335 |
IC50 (functional) | > 100 uM | Cytotoxicity in the absence of thymidine and hypoxanthine against CCRF-CEM cell line | ChEMBL. | 10888335 |
Inhibition (binding) | % | In vitro inhibitory activity against Aminoimidazole carboxamide ribonucleotide transformylase pre-incubated for 12 hr at 250 microM; Not active. | ChEMBL. | 10888335 |
Inhibition (binding) | 0 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 3 min at 250 uM; Not active | ChEMBL. | 10888335 |
Inhibition (binding) | 0 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 30 min at 250 uM; Not active | ChEMBL. | 10888335 |
Inhibition (binding) | 0 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 8 hr at 250 uM; Not active | ChEMBL. | 10888335 |
Inhibition (binding) | NA 0 % | In vitro inhibitory activity against Aminoimidazole carboxamide ribonucleotide transformylase pre-incubated for 12 hr at 250 microM; Not active. | ChEMBL. | 10888335 |
Inhibition (binding) | = 87 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) following 3 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 87 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) following 3 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 94 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) following 30 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 94 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) following 30 min pre-incubation at 250 microM concentration | ChEMBL. | 10888335 |
Inhibition (binding) | = 98 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 8 hr at 250 uM | ChEMBL. | 10888335 |
Inhibition (binding) | = 98 % | In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 8 hr at 250 uM | ChEMBL. | 10888335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.